Abstract.
We present a new version of P systems called Client-Server P Systems (CSPS). The client membranes are characterized by their states; the server membrane stores the states of the clients andtriggers the corresponding interaction rules. We show that CSPS have the same expressive power as Turing machines. CSPS is used to model various molecular processes in which interaction and state transitions are causally linked. Signaling pathways and T cell activation are described by using a CSPS software environment called MOlNET (MOlecular NETworks). MOlNET can describe the dynamics of molecular interactions, including both qualitative and quantitative aspects and simulating the signaling pathways that tune the activation thresholds for T cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bhalla, U., Iyengar, R., Emergent Properties of Networks of Biological Signaling Pathways, Science 283, 381–387, 1999.
Chan, C., Modeling T cell activation, PhD thesis, Centre for Nonlinear Dynamics and its Applications, University College London, 2002.
Ciobanu, G., Paraschiv, D., P System Software Simulator, Fundamenta Informaticae 49, 61–66, 2002.
Ciobanu, G., Tanasă, B., Dumitriu, D., Huzum, D., Moruz, G., Molecular Networks as Communicating Membranes. In Gh. Păun, C. Zandron (Eds.), Proc. Workshop On Membrane Computing, MolCoNet vol.1, 163–175, 2002.
Ciobanu, G., Tanasă, B., Dumitriu, D., Huzum, D., Moruz, G., Simulation and prediction of T cell responses, Proc. 3rd Intl.Conf. on Systems Biology, 2002.
Dassow, J., Păun, Gh., Regulated Rewriting in Formal Language Theory, Springer, Berlin, 1989.
Grossman, Z., Singer, A., Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus, PNAS 93, 14747–14752, 1996.
Kaufman, M., Andris, F., Leo, O., A logical analysis of T cell activation and anergy, PNAS 96, 3894–3899, 1999.
Martín-Vide, C., Păun, A., Păun, Gh., On the Power of P Systems with Symport Rules, JUCS 8, 317–331, 2002.
Myung, P., Boerthe, N., Koretzky, G., Adapter proteins in lymphocyte antigenreceptor signaling, Current Opinion in Immunology 12, 256–266, 2000.
Păun, A., Păun, Gh., The power of communication: P systems with symport/ antiport, New Generation Computing 20, 295–306, 2002.
Păun, Gh., Computing with membranes, Journal of Computer and System Sciences 61, 108–143, 2000.
Rao, N., Dodge, I., Band, H., The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system, Journal of Leukocyte Biology 71, 753–763, 2002.
Rozenberg, G., Salomaa, A., Handbook of Formal Languages, Springer, 1997.
Rudd, C., Schneider, H., Cbl sets the threshold for autoimmunity, Current Biology 10, 344–347, 2000.
Tomita, M., Whole-cell simulation: a grand challenge of the 21st century, Trends in Biotechnology 19, 205–210, 2001.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ciobanu, G., Dumitriu, D., Huzum, D., Moruz, G., TanasĂ, B. (2003). Client–Server P Systems in Modeling Molecular Interaction. In: PĂun, G., Rozenberg, G., Salomaa, A., Zandron, C. (eds) Membrane Computing. WMC 2002. Lecture Notes in Computer Science, vol 2597. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36490-0_13
Download citation
DOI: https://doi.org/10.1007/3-540-36490-0_13
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-00611-4
Online ISBN: 978-3-540-36490-0
eBook Packages: Springer Book Archive