Abstract
The last decade has seen a revolution in the field of Immunology. Starting from simple views on the ability of the immune system to respond to foreign antigens or to perform self/not-self discrimination, the image has become much more complex, with the realisation that autoreactive lymphocytes normally circulate in the body, without causing harm to the organism. In fact, the critical point in the development of an immune response is the activation of lymphocytes. This depends on the functional state of antigen-presenting cells and on structural features of the so-called “immune synapse”. Self/not-self discrimination is therefore not as strict as previously thought: on the contrary, it has been shown that a certain degree of self-reactivity is useful, if not necessary, to the homeostasis of the organism. Furthermore, the immune system can be viewed as a network of elements which try to connect with each other to avoid death, and are endowed with emerging properties. In this review, we will make a quick summary of the “classical” paradigms in Immunology, and will discuss the dogmas (specificity, self/not-self discrimination, tolerance) as well as the new ideas to explain how the immune system works, all of them emerging from experimental observations made in the last decade of immunological research. All this may have interesting consequences both for immunologists wanting to make mathematical models of the Immune System and for those involved in the use of immune algorithms for the development of “Artificial Immune Systems” and computational applications.
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References
Akira, S., Sato, S.: Toll-like receptors and their signaling mechanisms. Scandinavian Journal of Infectious Diseases 35(9), 555–562 (2003)
Bankovich, A.J., Girvin, A.T., Moesta, A.K., Garcia, K.: Peptide register shifting within the MHC groove: theory becomes reality. Molecular Immunology 40(14-15), 1033–1039 (2004)
Bretscher, P., Cohn, M.: A theory of self-nonself discrimination. Science 169(950), 1042–1049 (1970)
Burnet, F.M.: A modification of Jerne’s theory of antibody production using the concept of clonal selection. Cancer Journal for Clinicians 26(2), 119–121 (1976)
Cohen, I.R., Hershberg, U., Solomon, S.: Antigen-receptor degeneracy and immunological paradigms. Molecular Immunology 40(14-15), 993–996 (2004)
Coutinho, A., Haas, W.: In vivo models of dominant T-cell tolerance: where do we stand today? Trends in Immunology 22(7), 350–351 (2001)
Coutinho, A., Hori, S., Carvalho, T., Caramalho, I., Demengeot, J.: Regulatory T cells: the physiology of autoreactivity in dominant tolerance and quality control of immune responses. Immunological Reviews 182, 89–98 (2001)
Delon, J., Germain, R.N.: Information transfer at the immunological synapse. Current Biology 10(24), R923-33,-28 (2000)
Edelman, G.M., Gally, J.A.: Degeneracy and complexity in biological systems. Proceedings of the National Academy of Sciences of the United States of America 98(24), 13763–13768 (2001)
Germain, R.N.: An innately interesting decade of research in immunology. Nature Medicine 10(12), 1307–1320 (2004)
Haskins, K., Kappler, J., Marrack, P.: The major histocompatibility complex-restricted antigen receptor on T cells. Annual Review of Immunology 2, 51–66 (1984)
Huppa, J.B., Davis, M.M.: T-cell-antigen recognition and the immunological synapse. Nature Reviews. Immunology. 3(12), 973–983 (2003)
Jerne, N.: Towards a network theory of the immune system. Annales d’Immunologie 125(1-2), 373–389 (1974)
Kappler, J.W., Roehm, N., Marrack, P.: T cell tolerance by clonal elimination in the thymus. Cell 49(2), 273–280 (1987)
Krummel, M.F., Davis, M.M.: Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Current Opinion in Immunology 14(1), 66–74 (2002)
Lanzavecchia, A.: Antigen-specific interaction between T and B cells. Nature 314(6011), 537–539 (1985)
Mathis, D., Benoist, C.: Back to central tolerance. Immunity, 509–516 (2004)
Matzinger, P.: Tolerance, danger, and the extended family. Annual Review of Immunology 12, 991–1045 (1994)
Medzhitov, R., Janeway Jr., C.: The Toll receptor family and microbial recognition. Trends in Microbiology 8(10), 452–456 (2000)
Mellman, I.: Antigen processing and presentation by dendritic cells: cell biological mechanisms. Advances in Experimental Medicine & Biology 560, 63–67 (2005)
Moretta, L., Bottino, C., Pende, D., Vitale, M., Mingari, M.C., Moretta, A.: Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis. Immunology Letters 100(1), 7–13 (2005)
Nishimura, E., Sakihama, T., Setoguchi, R., Tanaka, K., Sakaguchi, S.: Induction of antigenspecific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. International Immunology 16(8), 1189–1201 (2004)
Park, Y., Moon, Y., Chung, H.Y.: AIRE-1 (autoimmune regulator type 1) as a regulator of the thymic induction of negative selection. Annals of the New York Academy of Sciences 1005, 431–435 (2003)
Paterson, H.M., Murphy, T.J., Purcell, E.J., Shelley, O., Kriynovich, S.J., Lien, E., Mannick, J.A., Lederer, J.A.: Injury primes the innate immune system for enhanced Toll-like receptor reactivity. Journal of Immunology 171(3), 1473–1483 (2003)
Shoenfeld, Y.: The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies. Nature Medicine 10(1), 17–18 (2004)
Skoberne, M., Beignon, A.S., Bhardwaj, N.: Danger signals: a time and space continuum. Trends in Molecular Medicine 10(6), 251–257 (2004)
Steinman, R.M., Bonifaz, L., Fujii, S., Liu, K., Bonnyay, D., Yamazaki, S., Pack, M., Hawiger, D., Iyoda, T., Inaba, K., Nussenzweig, M.: The innate functions of dendritic cells in peripheral lymphoid tissues. Advances in Experimental Medicine & Biology 560, 83–97 (2005)
Szyper-Kravitz, M., Zandman-Goddard, G., Lahita, R.G., Shoenfeld, Y.: The neuroendocrineimmune interactions in systemic lupus erythematosus: a basis for understanding disease pathogenesis and complexity. Rheumatic Diseases Clinics of North America 31(1), 161–175 (2005)
Tonegawa, S., Steinberg, C., Dube, S., Bernardini, A.: Evidence for somatic generation of antibody diversity. Proceedings of the National Academy of Sciences of the United States of America 71(10), 4027–4031 (1974)
Tracey, K.J.: The inflammatory reflex. Nature 420(6917), 853–859 (2002)
Varela, F.J., Coutinho, A.: Second generation immune networks. [Review] [59 refs]. Immunology Today 12(5), 159–166 (1991)
von Boehmer, H.: Mechanisms of suppression by suppressor T cells. Nature Immunology 6(4), 338–344 (2005)
Zinkernagel, R.M., Doherty, P.C.: Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248(450), 701–702 (1974)
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Cesana, E., Beltrami, S., Laface, A.E., Urthaler, A., Folci, A., Clivio, A. (2006). Current Paradigms in Immunology. In: Apolloni, B., Marinaro, M., Nicosia, G., Tagliaferri, R. (eds) Neural Nets. WIRN NAIS 2005 2005. Lecture Notes in Computer Science, vol 3931. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11731177_32
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