Abstract
The paper presents a permutation-based algorithm for predicting RNA secondary structure. It is practicable, and can be used to predict real RNA molecules. The conception of permutation is introduced, which is the start point of our algorithm. Individual is represented as a permutation of stem list. Crossover operator, mutation operator, and selection strategy are designed to be compatible with such an individual representation. At the end of the paper, a comparison between our result and that from RNAstructure is outlined. It is proved that our algorithm has achieved comparable or better result than RNAstructure.
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Zuker, M., Stiegler, P.: Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. Nucleic Acids Res. 9, 133–148 (1981)
Gultyaev, A.P., Van Batenburg, F.H.D., Pleij, C.W.A.: The computer simulation of RNA folding pathways using a genetic algorithm. J. Mol. Biol. 250, 37–51 (1995)
Wiese, K.C., Glen, E.: A Permutation Based Genetic Algorithm for the RNA Folding Problem: A Critical Look at Selection Strategies, Crossover Operators and Representation Issues. BioSystems-Special Issue on Computational Intelligence in Bioinformatics (2003)
Mathews, D.H., Sabina, J., Zuker, M., Turner, D.H.: Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J. Mol. Biol. 288, 911–940 (1999)
Wiese, K.C., Goodwin, S.D.: Keep-Best Reproduction: A Local Family Competition Selection Strategy and the Environment it Flourishes in. Constraints 6, 399–422 (2001)
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© 2005 Springer-Verlag Berlin Heidelberg
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Zhan, Y., Guo, M. (2005). A Permutation-Based Genetic Algorithm for Predicting RNA Secondary Structure—A Practicable Approach. In: Wang, L., Jin, Y. (eds) Fuzzy Systems and Knowledge Discovery. FSKD 2005. Lecture Notes in Computer Science(), vol 3614. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11540007_107
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DOI: https://doi.org/10.1007/11540007_107
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-28331-7
Online ISBN: 978-3-540-31828-6
eBook Packages: Computer ScienceComputer Science (R0)