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Conceptual Modeling of Genetic Studies and Pharmacogenetics

  • Conference paper
Computational Science and Its Applications – ICCSA 2005 (ICCSA 2005)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 3482))

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Abstract

Genetic Studies examine relationships between genetic variation and disease development. Pharmacogenetics studies the responses to drugs against genetic variation. These two lines of research evaluate relationships among genotype, phenotype, and environment regarding subjects. These studies demand a variety of other information; such as clinical observations, disease development history, demographics, life style, and living environment. Correct and informative modeling of these data is critical for bioinformaticians; the model affects the capacity of data manipulation and the types of queries they can ask as well as performance of the implemented system. In this paper, we present a conceptual model on genetic studies and Pharmacogenetics using Unified Modeling Language (UML). Our model provides a comprehensive view of integrated data for genetic studies and Pharmacogenetics by incorporating genomics, experimental data, domain knowledge, research approaches, and interface data for other publicly available resources into one cohesive model. Our model can support diverse biomedical research activities that use both clinical and biomedical data to improve patient care through incorporation of the roles of environment, life style and genetics. Our model consists of a set of class diagrams organized into a hierarchy of packages diagrams to clearly and intuitively show inter-object relationships at different levels of complexity.

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Author information

Authors and Affiliations

  1. College of Information Science and Technology, Drexel University, 3141 Chestnut Street, Philadelphia, PA, 19104, USA

    Xiaohua Zhou & Il-Yeol Song

Authors
  1. Xiaohua Zhou
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  2. Il-Yeol Song
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Editor information

Editors and Affiliations

  1. Department of Mathematics and Computer Science, University of Perugia, via Vanvitelli, 1, I-06123, Perugia, Italy

    Osvaldo Gervasi

  2. Department of Computer Science, University of Calgary, 2500 University Drive N.W., T2N 1N4, Calgary, AB, Canada

    Marina L. Gavrilova

  3. William Norris Professor, Head of the Computer Science and Engineering, Department University of Minnesota, USA

    Vipin Kumar

  4. Department of Chemistry, University of Perugia, Via Elce di Sotto, 8, I-06123, Perugia, Italy

    Antonio Laganà

  5. Institute of High Performance Computing, IHCP, 1 Science Park Road, 01-01 The Capricorn, Singapore Science Park II, 117528, Singapore

    Heow Pueh Lee

  6. School of Computing, Soongsil University, Seoul, Korea

    Youngsong Mun

  7. Clayton School of IT, Monash University, 3800, Clayton, Australia

    David Taniar

  8. OptimaNumerics Ltd, Belfast, United Kingdom

    Chih Jeng Kenneth Tan

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© 2005 Springer-Verlag Berlin Heidelberg

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Zhou, X., Song, IY. (2005). Conceptual Modeling of Genetic Studies and Pharmacogenetics. In: Gervasi, O., et al. Computational Science and Its Applications – ICCSA 2005. ICCSA 2005. Lecture Notes in Computer Science, vol 3482. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11424857_43

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  • DOI: https://doi.org/10.1007/11424857_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25862-9

  • Online ISBN: 978-3-540-32045-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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