TCL1A

TCL1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JSG
Dynodwyr
Cyfenwau	TCL1A, TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A
Dynodwyr allanol	OMIM: 186960 HomoloGene: 7565 GeneCards: TCL1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein kinase binding • identical protein binding • protein serine/threonine kinase activator activity Cydrannau o'r gell • cytoplasm • Reticwlwm endoplasmig • intracellular membrane-bounded organelle • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • multicellular organism development • positive regulation of cell population proliferation • positive regulation of mitochondrial membrane potential • positive regulation of protein oligomerization • positive regulation of peptidyl-serine phosphorylation • negative regulation of apoptotic process • protein homotrimerization • cellular response to tumor necrosis factor • positive regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8115	n/a
Ensembl	ENSG00000100721	n/a
UniProt	P56279	n/a
RefSeq (mRNA)	NM_001098725 NM_021966	n/a
RefSeq (protein)	NP_001092195 NP_068801 NP_001092195.1 NP_068801.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TCL1A yw TCL1A a elwir hefyd yn T-cell leukemia/lymphoma 1A, isoform CRA_b a T-cell leukemia/lymphoma 1a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q32.13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TCL1A.

• TCL1

• "Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival. ". Oncotarget. 2015. PMID 26299617.
• "TCL1 expression predicts overall survival in patients with mantle cell lymphoma. ". Eur J Haematol. 2015. PMID 25688912.
• "TCL-1-positive hematogones in a patient with T-cell prolymphocytic leukemia after therapy. ". Hum Pathol. 2017. PMID 28232160.
• "T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer. ". Biomed Pharmacother. 2017. PMID 28178623.
• "TCL1 expression patterns in Waldenström macroglobulinemia.". Mod Pathol. 2016. PMID 26493619.