PRDM2

PRDM2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JV0, 2QPW
Dynodwyr
Cyfenwau	PRDM2, HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2, PR domain 2, PR/SET domain 2, KMT8A
Dynodwyr allanol	OMIM: 601196 HomoloGene: 40822 GeneCards: PRDM2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • DNA binding • zinc ion binding • histone-lysine N-methyltransferase activity • metal ion binding • nucleic acid binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin DNA binding • sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell • Golgi apparatus Prosesau biolegol • histone lysine methylation • methylation • GO:0009373 regulation of transcription, DNA-templated • determination of adult lifespan • transcription, DNA-templated • transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7799	n/a
Ensembl	ENSG00000116731	n/a
UniProt	Q13029	n/a
RefSeq (mRNA)	NM_001007257 NM_001135610 NM_012231 NM_015866 NM_001393986 NM_001393987 NM_001393988	n/a
RefSeq (protein)	NP_001007258 NP_001129082 NP_036363 NP_056950	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRDM2 yw PRDM2 a elwir hefyd yn PR domain zinc finger protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.21.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRDM2.

• "Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas. ". BMC Cancer. 2015. PMID 25884948.
• "Alteration in gene expression profile and oncogenicity of esophageal squamous cell carcinoma by RIZ1 upregulation. ". World J Gastroenterol. 2013. PMID 24115813.
• "RIZ1 and histone methylation status in pituitary adenomas. ". Tumour Biol. 2017. PMID 28718376.
• "RIZ1: a potential tumor suppressor in glioma. ". BMC Cancer. 2015. PMID 26690953.
• "Aberrant Methylation of the 1p36 Tumor Suppressor Gene RIZ1 in Renal Cell Carcinoma.". Asian Pac J Cancer Prev. 2015. PMID 25987089.