BRAF

BRAF
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1UWH, 1UWJ, 2FB8, 2L05, 3C4C, 3D4Q, 3IDP, 3II5, 3NY5, 3OG7, 3PPJ, 3PPK, 3PRF, 3PRI, 3PSB, 3PSD, 3Q4C, 3Q96, 3SKC, 3TV4, 3TV6, 4DBN, 4E26, 4E4X, 4EHE, 4EHG, 4FC0, 4FK3, 4G9C, 4G9R, 4H58, 4JVG, 4KSP, 4KSQ, 4MBJ, 4MNE, 4MNF, 4PP7, 4WO5, 5C9C, 5CT7, 4XV2, 4XV1, 4XV9, 4XV3, 4R5Y, 5CSW, 5CSX, 4YHT, 5J2R, 5FD2, 5HIE, 5HID, 5HI2, 4CQE, 5J18
Dynodwyr
Cyfenwau	BRAF, B-RAF1, BRAF1, NS7, RAFB1, B-Raf, B-Raf proto-oncogene, serine/threonine kinase
Dynodwyr allanol	OMIM: 164757 HomoloGene: 3197 GeneCards: BRAF
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein kinase activity; • calcium ion binding; • nucleotide binding; • transferase activity; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • small GTPase binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • ATP binding; • MAP kinase kinase kinase activity; • mitogen-activated protein kinase kinase binding; • protein heterodimerization activity;
Cydrannau o'r gell	• intracellular membrane-bounded organelle; • bilen; • cnewyllyn cell; • intracellular anatomical structure; • cytoplasm; • cytosol; • Cellbilen; • mitocondria; • neuron projection; • cell body;
Prosesau biolegol	• cellular response to calcium ion; • GO:0007243 intracellular signal transduction; • phosphorylation; • establishment of protein localization to membrane; • negative regulation of apoptotic process; • positive regulation of peptidyl-serine phosphorylation; • protein phosphorylation; • animal organ morphogenesis; • GO:0072468 signal transduction; • negative regulation of signal transduction; • positive regulation of glucose transmembrane transport; • trehalose metabolism in response to stress; • MAPK cascade; • GO:1901313 positive regulation of gene expression; • cell differentiation; • positive regulation of ERK1 and ERK2 cascade; • myeloid progenitor cell differentiation; • visual learning; • negative regulation of fibroblast migration; • thyroid gland development; • somatic stem cell population maintenance; • regulation of cell population proliferation; • CD4-positive, alpha-beta T cell differentiation; • positive T cell selection; • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; • response to peptide hormone; • GO:1904089 negative regulation of neuron apoptotic process; • regulation of T cell differentiation; • alpha-beta T cell differentiation; • thymus development; • regulation of axon regeneration; • positive regulation of axon regeneration; • positive regulation of axonogenesis; • T cell receptor signaling pathway; • protein heterooligomerization; • positive regulation of stress fiber assembly; • response to cAMP; • long-term potentiation; • head morphogenesis; • face development; • positive regulation of substrate adhesion-dependent cell spreading; • cellular response to nerve growth factor stimulus; • negative regulation of synaptic vesicle exocytosis; • negative regulation of endothelial cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	673
	n/a
	ENSG00000157764
	n/a
	P15056
	n/a
	NM_004333; NM_001354609; NM_001374244; NM_001374258
	n/a
NP_004324; NP_001341538; NP_001361173; NP_001361187; NP_001365396;
	NP_001365397; NP_001365398; NP_001365399; NP_001365400; NP_001365401; NP_001365402; NP_001365403; NP_001365404
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BRAF yw BRAF a elwir hefyd yn Serine/threonine-protein kinase B-raf a B-Raf proto-oncogene, serine/threonine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q34.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BRAF.

NS7
B-raf
BRAF1
RAFB1
B-RAF1

Llyfryddiaeth

"Expression of the BRAF L597Q mutation in sporadic neurofibromas of the upper extremity. ". Exp Mol Pathol. 2017. PMID 29162506.
"Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study. ". Br J Cancer. 2017. PMID 28972961.
"Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas: Expanding the Genetic Spectrum of Tumors With Overlapping Features With Infantile Fibrosarcoma. ". Am J Surg Pathol. 2018. PMID 28877062.
"BRAF V600E Mutations Occur in a Subset of Glomus Tumors, and Are Associated With Malignant Histologic Characteristics. ". Am J Surg Pathol. 2017. PMID 28834810.
"Gliosarcomas with the BRAFV600E mutation: a report of two cases and review of the literature.". J Clin Pathol. 2017. PMID 28775171.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BRAF - Cronfa NCBI

[1]

[2]