CTSS

CTSS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GLO, 1MS6, 1NPZ, 1NQC, 2C0Y, 2F1G, 2FQ9, 2FRA, 2FRQ, 2FT2, 2FUD, 2FYE, 2G6D, 2G7Y, 2H7J, 2HH5, 2HHN, 2HXZ, 2OP3, 2R9M, 2R9N, 2R9O, 3IEJ, 3KWN, 3MPE, 3MPF, 3N3G, 3N4C, 3OVX, 4P6E, 4P6G
Dynodwyr
Cyfenwau	CTSS, cathepsin S
Dynodwyr allanol	OMIM: 116845 HomoloGene: 20867 GeneCards: CTSS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • fibronectin binding • cysteine-type peptidase activity • collagen binding • GO:0070122 peptidase activity • cysteine-type endopeptidase activity • laminin binding • hydrolase activity • proteoglycan binding • serine-type endopeptidase activity Cydrannau o'r gell • intracellular membrane-bounded organelle • extracellular region • endolysosome lumen • lysosomal lumen • lysosome • extracellular space • tertiary granule lumen • ficolin-1-rich granule lumen • collagen-containing extracellular matrix • late endosome Prosesau biolegol • positive regulation of cation channel activity • antigen processing and presentation • adaptive immune response • antigen processing and presentation of exogenous peptide antigen via MHC class II • protein processing • extracellular matrix disassembly • proteolysis • toll-like receptor signaling pathway • antigen processing and presentation of peptide antigen • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • cellular response to thyroid hormone stimulus • collagen catabolic process • proteolysis involved in cellular protein catabolic process • basement membrane disassembly • response to acidic pH • neutrophil degranulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1520	n/a
Ensembl	ENSG00000163131	n/a
UniProt	P25774	n/a
RefSeq (mRNA)	NM_004079 NM_001199739	n/a
RefSeq (protein)	NP_001186668 NP_004070	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTSS yw CTSS a elwir hefyd yn Cathepsin S (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.^[2]

• "Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer. ". Biomaterials. 2016. PMID 27372424.
• "Association between SNPs in the promoter region in cathepsin S and risk of asthma in Chinese Han population. ". Eur Rev Med Pharmacol Sci. 2016. PMID 27249607.
• "Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer. ". Oncotarget. 2016. PMID 27058412.
• "Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. ". Nat Cell Biol. 2014. PMID 25086747.
• "Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist.". PLoS One. 2014. PMID 24964046.