Recent Discoveries and Clinical Applications of Deoxyribonucleic Acid (DNA) Methylation Inhibitors in the Diagnosis, Classification, and Treatment of Meningiomas

محل انتشار: مجله بین المللی تحقیقات پیشرفته زیست شناختی و زیست پزشکی، دوره: 13، شماره: 2

سال انتشار: 1404

نوع سند: مقاله ژورنالی

زبان: انگلیسی

مشاهده: 46

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https://civilica.com/doc/2145160

شناسه ملی سند علمی:

JR_IJABBR-13-2_004

تاریخ نمایه سازی: 11 دی 1403

چکیده مقاله:

Recent advancements in molecular biology and genomics have revolutionized our understanding of meningiomas, leading to novel diagnostic and treatment strategies. Meningiomas are common central nervous system tumors and their management has traditionally relied on histopathological classification. However, the integration of DNA methylation analysis has provided new understanding into the molecular activities of these tumors, providing potential biomarkers for personalized medicine. This review involved a comprehensive search of electronic databases (e.g., PubMed, Web of Science, and Scopus) was conducted to identify relevant studies based on keywords related to DNA methylation inhibitors, meningioma, diagnosis, classification, and treatment. This study was aimed at assessing the recent discoveries regarding DNA methylation inhibitors and their potential clinical applications in diagnosing, classifying, and treating meningiomas. DNA methylation inhibitors are applied in modulating gene expression patterns in meningiomas and Nucleoside analogs demonstrated potential in inhibiting meningioma cell growth by inducing apoptosis through DNA hypomethylation. These inhibitors, when used in combination with conventional treatments, could enhance treatment efficacy, overcome drug resistance, and reduce tumor recurrence, as they can be specifically used to target specific molecular subtypes of meningiomas.

کلیدواژه ها:

DNA methylation inhibitor ، Meningioma ، Biomarkers ، Treatment Strategies

نویسندگان

Inusah Abdul-Hanan Saani

University for Development Studies, Ghana

Ahorlu Elim

University for Development Studies, Ghana

Ziblim Andrew

University for Development Studies, Ghana

Gbayisomore Tolulope Judah

University of Benin Teaching hospital, Edo state, Nigeria

Omiyale Olumakinde Charles

Department of Pharmacology, Toxicology and Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria

Ike-Okpe Onyekachi

Enugu State University of Science and Technology, Nigeria

Ajayi Rufus

University of Illinois at Spingfield, Springfield, Illinois, USA

Nketsiah Esther

Clinical Rehabilitation Division, Nyaho Medical Centre, Accra, Ghana

Ayeni Lucky Aighowmafe

University of Wolverhampton, USA

Obe Feranmi Emmanuel

Department of Medical Laboratory Science, Ladoke Akintola University of Technology Ogbomoso, Nigeria

Alimi Kehinde Hikmat

Nigerian Institute of Medical Research, Lagos, Nigeria

Babalola Isaac Olamide

Ladoke Akintola University of Technology, Nigeria

Abimbola Esther Atinuke

Department of Biochemistry, Bayero University Kano, Nigeria

Ologbonjaye Kehinde

Department of Ecology and Evolutionary Biology, Tulane University, New Orleans Louisiana, Nigeria

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