NUCKS1

NUCKS1
Identifikatori
Aliasi	NUCKS1
Vanjski ID-jevi	OMIM: 611912 MGI: 1934811 HomoloGene: 23377 GeneCards: NUCKS1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	205,750,182 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	131,864,059 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • chromatin binding; • double-stranded DNA binding; • single-stranded DNA binding; • vezivanje sa RNK;
Ćelijska komponenta	• citoplazma; • jedro; • Hromatin; • Jedarce;
Biološki proces	• GO:1903106 positive regulation of insulin receptor signaling pathway; • transcription by RNA polymerase II; • glucose homeostasis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • interstrand cross-link repair; • regulation of DNA strand elongation; • cellular response to X-ray; • regulation of DNA replication; • Konverzija gena; • double-strand break repair via homologous recombination; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • replication fork processing; • cellular glucose homeostasis; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • GO:1903104 regulation of insulin receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	64710
	98415
	ENSG00000069275
	ENSMUSG00000026434
	Q9H1E3
	Q80XU3
	NM_022731
	NM_001145804; NM_175294
	NP_073568
	NP_001139276; NP_780503
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Jedarni sveprisutni ciklin-ovisni supstrat kazein–kinaze jest protein koji je kod ljudi kodiran genom NUCKS1 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 243 aminokiseline, a molekulska težina 27.296 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSRPVRNRKV	VDYSQFQESD	DADEDYGRDS	GPPTKKIRSS	PREAKNKRRS
GKNSQEDSED	SEDKDVKTKK	DDSHSAEDSE	DEKEDHKNVR	QQRQAASKAA
SKQREMLMED	VGSEEEQEEE	DEAPFQEKDS	GSDEDFLMED	DDDSDYGSSK
KKNKKMVKKS	KPERKEKKMP	KPRLKATVTP	SPVKGKGKVG	RPTASKASKE
KTPSPKEEDE	EPESPPEKKT	STSPPPEKSG	DEGSEDEAPS	GED

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069275 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026434 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ostvold AC, Norum JH, Mathiesen S, Wanvik B, Sefland I, Grundt K (Apr 2001). "Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo". Eur J Biochem. 268 (8): 2430–40. doi:10.1046/j.1432-1327.2001.02120.x. PMID 11298763.
^ "Entrez Gene: NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1".
^ "UniProt, Q9H1E3" (jezik: engleski). Pristupljeno 15. 12. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Thompson HG, Harris JW, Wold BJ, et al. (2003). "Identification and confirmation of a module of coexpressed genes". Genome Res. 12 (10): 1517–22. doi:10.1101/gr.418402. PMC 187523. PMID 12368243.
Grundt K, Skjeldal L, Anthonsen HW, et al. (2002). "A putative DNA-binding domain in the NUCKS protein". Arch. Biochem. Biophys. 407 (2): 168–75. doi:10.1016/S0003-9861(02)00513-1. PMID 12413487.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Grundt K, Haga IV, Aleporou-Marinou V, et al. (2004). "Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species". Biochem. Biophys. Res. Commun. 323 (3): 796–801. doi:10.1016/j.bbrc.2004.08.153. PMID 15381070.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Grundt K, Haga IV, Huitfeldt HS, Ostvold AC (2007). "Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS". Biochim. Biophys. Acta. 1773 (9): 1398–406. doi:10.1016/j.bbamcr.2007.05.013. PMID 17604136.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069275 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026434 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11298763-5] Ostvold AC, Norum JH, Mathiesen S, Wanvik B, Sefland I, Grundt K (Apr 2001). "Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo". Eur J Biochem. 268 (8): 2430–40. doi:10.1046/j.1432-1327.2001.02120.x. PMID 11298763.

[entrez-6] "Entrez Gene: NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1".

[UniProt-7] "UniProt, Q9H1E3" (jezik: engleski). Pristupljeno 15. 12. 2021.

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