HPCAL1

HPCAL1
Identifikatori
Aliasi	HPCAL1
Vanjski ID-jevi	OMIM: 600207 MGI: 1855689 HomoloGene: 37586 GeneCards: HPCAL1
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	10,427,617 bp
Lokacija gena (miš)
Hrom.	Hromosom 12 (miš)
Kraj	17,791,933 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ortolozi
	3241
	53602
	ENSG00000115756
	ENSMUSG00000071379
	P37235
	P62748
	NM_001258357; NM_001258358; NM_001258359; NM_002149; NM_134421
	NM_016677; NM_001361645
	NP_001245286; NP_001245287; NP_001245288; NP_002140; NP_602293
	NP_057886; NP_001348574
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hipokalcinoliki protein 1 jest protein koji je kod ljudi kodiran genom HPCAL1 sa hromosoma 2.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 193 aminokiseline, a molekulska težina 22.313 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGKQNSKLRP	EVLQDLRENT	EFTDHELQEW	YKGFLKDCPT	GHLTVDEFKK
IYANFFPYGD	ASKFAEHVFR	TFDTNGDGTI	DFREFIIALS	VTSRGKLEQK
LKWAFSMYDL	DGNGYISRSE	MLEIVQAIYK	MVSSVMKMPE	DESTPEKRTD
KIFRQMDTNN	DGKLSLEEFI	RGAKSDPSIV	RLLQCDPSSA	SQF

Funkcija

Protein kodiran ovim genom je član neuron-specifične porodice proteina koji vezuju kalcij u mrežnjači i mozgu.^[9] Veoma je sličan ljudskom hipokalcinskom proteinu i skoro identičan hipokalcinu sličnim-1 proteinima pacova i miša. Može biti uključen u kalcij ovisnu regulaciju fosforilacije rodopsina, a može biti od značaja za neuronsku signalizaciju u centralnom nervnom sistemu. Postoje dvije alternativno prerađene varijante transkripta ovog gena, sa više mjesta poliadenilacija.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115756 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071379 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta. 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222.
^ Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner". J Biol Chem. 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275.
^ ^a ^b "Entrez Gene: HPCAL1 hippocalcin-like 1".
^ "UniProt, P37235" (jezik: engleski). Pristupljeno 13. 4. 2022.
^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Dopunska literatura

Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res. 16 (2): 73–7. doi:10.1016/0168-0102(93)90074-Z. PMID 8387172. S2CID 4210072.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Spilker C, Richter K, Smalla KH, et al. (2000). "The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association". Neuroscience. 96 (1): 121–9. doi:10.1016/S0306-4522(99)00536-9. PMID 10683417. S2CID 22063490.
Bernstein HG, Baumann B, Danos P, et al. (2000). "Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain". J. Neurocytol. 28 (8): 655–62. doi:10.1023/A:1007056731551. PMID 10851344. S2CID 7944931.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Braunewell K, Riederer P, Spilker C, et al. (2001). "Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients". Dementia and Geriatric Cognitive Disorders. 12 (2): 110–6. doi:10.1159/000051244. PMID 11173883. S2CID 21446098.
Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513. PMID 11964161.
Spilker C, Gundelfinger ED, Braunewell KH (2002). "Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function". Biochim. Biophys. Acta. 1600 (1–2): 118–27. doi:10.1016/s1570-9639(02)00452-1. PMID 12445467.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pribanic S, Loffing J, Madjdpour C, et al. (2004). "Expression of visinin-like protein-3 in mouse kidney" (PDF). Nephron Physiology. 95 (4): 76–82. doi:10.1159/000074844. PMID 14694264. S2CID 4883128.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Jheng FF, Wang L, Lee L, Chang LS (2007). "Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins". Protein J. 25 (4): 250–6. doi:10.1007/s10930-006-9008-5. PMID 16703469. S2CID 29486237.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115756 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071379 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8038222-5] Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta. 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222.

[pmid14739275-6] Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner". J Biol Chem. 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275.

[entrez-7] "Entrez Gene: HPCAL1 hippocalcin-like 1".

[UniProt-8] "UniProt, P37235" (jezik: engleski). Pristupljeno 13. 4. 2022.

[pmid17311005-9] Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

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