DNAH14

DNAH14
Identifikatori
Aliasi	DNAH14
Vanjski ID-jevi	OMIM: 603341 MGI: 2444525 HomoloGene: 90078 GeneCards: DNAH14
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	225,399,292 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	181,643,339 bp
Ontologija gena
Molekularna funkcija	• microtubule motor activity; • nucleotide binding; • cytoskeletal motor activity; • ATP binding; • minus-end-directed microtubule motor activity; • dynein light chain binding; • dynein intermediate chain binding; • dynein light intermediate chain binding;
Ćelijska komponenta	• citoplazma; • projekcija ćelije; • Mikrotubula; • citoskelet; • Treplja; • dynein complex;
Biološki proces	• microtubule-based movement; • cilium assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	127602
	240960
	ENSG00000185842
	ENSMUSG00000047369
	Q0VDD8
	n/a
NM_001145154; NM_001373; NM_144989; NM_001349911; NM_001349912;
	NM_001367479; NM_001367481
	NM_172846; NM_001377039
NP_001138626; NP_659426; NP_001336840; NP_001336841; NP_001354408;
	NP_001354410
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Teški lanac 14 aksonsmnog dineina jest protein koji je kod ljudi kodiran genom DNAH14 sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 3.507 aminokiselina, a molekulska težina 399.895 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGRRSQWIWA	MRCQMLVPVL	SLHIGLARAL	GCGCIASKIE	CLIRCNAPFP
LLDAVGSVAS	QELQSLTGTV	GVTSGAAAYP	RWNLARARAP	PHLPGTQDPL
RRVRDPTPIV	ASSPGRRRGS	WSGGYGQEAS	EPGVVGLCCA	VLPIHPSLAL
AGVGGPDLRR	FQEGPQRPSD	HGAAEKHMET	FIPIDLTTEN	QEMDKEETKT
KPRLLRYEEK	KYEDVKPLET	QPAEIAEKET	LEYKTVRTFS	ESLKSEKTEE
PKDDDVIRNI	IRLREKLGWQ	TILPQHSLKY	GSSKIAIQKI	TLKKPLEDDG
EFVYCLPRKS	PKSLYNPYDL	QVVSAHTAKH	CKEFWVITAS	FISKLDSSRT
YSLDEFCEEQ	LQQATQALKQ	LEDIRNKAIS	EMKSTFLKVA	EKNEIKEYFE
SKLSEDDTTH	FKLPKYRRLL	ETFFKFVMLV	DYIFQELIRQ	LMNTAVTLLL
ELFNGSAGMP	FSVEKKNENL	IRTFKDNSFP	TGKTTNDCEE	LVDNSKLHAI
SVQKSEVKTD	TDINEILNSV	EVGKDLRKTY	APIFEVNLCL	RIPAESDSSE
NSKENFHESD	QCPEECVMFE	DEMSENKDNC	VKKHSSEELL	PKAKKSKEIS
YNLEDIISAT	ITPLCQDPQL	SIFIDLVSIM	DLPNKTGSII	HYKEQTRWPD
CHILFETDPA	YQNIIVNLLT	IIGNSMGLVN	AYSHKFIKYC	TMTEKAKIMS
MKISSMGELT	SKEFEAILNR	FRNYFRHIVN	MAIEKRIGIF	NVVVESSLQQ
LECDPTEIEE	FLEHFIFLNA	ISSKISKLEK	EFLTMSQLYS	VAKHHQIHIS
EEQIAIFQVL	LLKFSQLKSS	MKLSKINKDT	AITKFRDNLE	ACISGLHVDV
GNLKAKIRTP	LLLCAGTQVS	TAMEMIQTLS	GEAASLTNKA	KAYSHYQDCF
SDSQSHMHSV	NVEEITQIVL	SEISDIEGDL	TLRKKLWEAQ	EEWKRASWEW
RNSSLQSIDV	ESVQRNVSKL	MHIISVLEKE	IYSIFIIPSI	DDISAQLEES
QVILATIKGS	PHIGPIKSQI	MFYNDCVKSF	VSSYSREKLE	KVHAGLMCHL
EEVADLVVLD	TSNSRTKAIL	GALLILYVHC	RDIVINLLLK	NIFNAEDFEW
TRHLQYKWNE	KQKLCYVSQG	NASFTYGYEY	LGCTSRLVIT	PLTDRCWLTL
MEALHLNLGG	CPAGPAGTGK	TETVKDLAKC	ALFAFKCNTA	LIKLPNSLIV
LTCFGLEKTV	LVMNTVMSFR	FVLEGKEIRI	NMSCAVFITM	NPRYGGGVEL
PDNLKSLFRP	VAMMVPHYQM	IAEIILFSFG	FKSANSLSGK	LTNLYELARK
QLSQQDHYNF	GLRSLKIVLI	MAGTKKREFK	CDTSDSLSEA	DETLIVIEAI
REASLPKCPP	EDVPLFENII	GDIFPEVTVL	KVNQLALEKV	IYTATQQLGL
QNWSSQKEKI	IQFYNQLQVC	VGVMLVGPTG	GGKTTVRRIL	EKALTLLPIA
DFLSVAERKS	ASKISERKGK	VDICVLNPKC	VTLSELYGQL	DPNTMEWTDG
LLSATIRSYV	YFNTPKNTKK	DIDLRLKSRI	SDLSNVFKLD	SSDTTETDDN
IFEEIEKVVK	IPENHNFDWQ	WIILDGPVDT	FWVENLNSVL	DDTRTLCLAN
SERIALTNKI	RVIFEVDNLS	QASPATVSRC	AMVYMDPVDL	GWEPYVKSWL
LKTSKIISQS	GVDCLEFMIK	NSVTDGLQFI	RNRQKFQPYP	MEDITVVITL
CRILDAFFDF	MGKNGGFEQS	DDLNDTSSKE	ANSQRESVTF	KDIEKRDENT
WYPEKNPDKL	TKIIQKLFVF	AFTWAFGGAL	NREDEHRENI	PFCPSLEPDS
LAKVTYDFDK	LVHELFGNSS	QVGINLPTGE	CSIFGYFVDI	EQCEFIPWSD
LVPNDQTLIQ	RDNPTKKPEV	RTNKKLLKNN	DHKGVVVSTI	NFSTNVTAAK
TKEMILKKLI	RRTKDTLGAP	KNNRILIFID	DMNMPVSDMY	GAQPPLELIR
QLLDLGGVYD	TEKNTWKNIQ	DLSIVAACVP	VVNDISPRLL	KHFSMLVLPH
PSQDILCTIF	QIGIDGCGKK	TCATLACYLT	DNKLYRVPIS	HKCAYIEFKE
VFKKVFIHAG	LKGKPTVLMV	PNLNIEQDSF	LEDLNYIISS	GRIPDLFENV
ELDSIAMKIR	YLTEQSGHMD	NRQSLLSFFQ	KRIYKNLHIF	VIMSPEGPSF
RQNCRVYPSM	ISSCTIDWYE	RWPEEALLIV	ANSFLKEKVN	FENRENLKEK
LAPTCVQIHK	SMKDLNRKYF	EETGRFYYTT	PNSYLQFMET	FAHILRAREE
EMQTKRDRFH	MGLSTILEAT	TLVTEMQEEL	LILGPQVEQK	TKETETLMEK
LRKDSQVVEK	VQMLVKQDEE	IVAEEVRIVE	DYAQKTANEL	KSVLPAFDKA
IVALNALDKA	DVAELRVYTR	PPFLVLTVMN	AVCILLQKKP	NWATAKLLLS
ETGFLKKLIN	LDKDSIPDKV	FVKLKKIVTL	PDFNPHKISL	VSVACCSLCQ
WVIALNNYHE	VQKVVGPKQI	QVAEAQNVLK	IARQRLAEKQ	RGLQLISRWH
NQGLPHGQYS	VENAILIKNG	QQWPLLIDPH	RQAHKWIRQM	EGSRLQKLSI
EDSNYTKKIE	NAMKTGGSVL	LQSCQASTWR	KKLYLSTEID	NPHFLPSVYN
FVTMINFTVT	FQGLQDQLLS	TVVTHEVPHL	EDQRSKLLES	ISLDAITLEE
LEEKTLNLLQ	KALGSILDDD	KIVDTLRKSK	MTSNEISKRI	EATKKAESEI
QAIRKNYLPI	ATRGALLYFL	VADLTQINYM	YQFSLDWFHQ	VFVSSVVSKS
KEQEHSFKRE	KVSPKEVHEF	ISISKEPNLE	NEKNLLDKHI	KSAIDMLTKS
IFKVVSSALF	NEDKLCFSFR	LCTVIMQNNA	NGNLIQDDIG	FLPEEEWNIF
LYSGILINIK	SALSQSRLTS	TFEIGESQHL	QWLSDSRWRQ	CQYVSTHLEP
FSLLCKSLLS	NVSQWDTFKN	SKAVYSLIST	PFSSENASLE	ENTKPPEEKH
TFCLLLRAIN	HTGTDLGPVG	RGQWLTSTAC	DRHTDVCSFS	FALNDGVPDV
EHVQDIFYGH	CVDKYHVKVL	RPESLNNSVR	KFITEKMGNK	YLQRTGVNLK
DAYKGSNART	PLILIQTHGS	ASIKDYIHII	QSLPDDDLPE	VLGIHPEAIR
SCWETQGEKF	IENLIAMQPK	TTTANLMIRP	EQSKDELVME	ILSDLLKRLP
LTVEKEEIAV	GTPSTLKSMM	SSSIWESLSK	NLKDHDPLIH	CVLLTFLKQE
IKRFDKLLFV	IHKSLKDLQL	AIKGEIILTQ	ELEEIFNSFL	NMRVPTLWQK
HAYRSCKPLS	SWIDDLIQRL	NFFNTWAKVA	YTAIQRRYMR	FVTVWKQSIP
STSQKCKHPE	DSENNFFEGF	PSRYWLPAFF	FPQAFLAAVL	QDYGRSRGIA
VDALTFTHHV	ISNTTDKDEK	FSVFMPKKLN	IVRRAFKGSA	SSHTGVYIFG
LFIEGARWNR	EQKILEDSLP	LEMCCDFPDI	YFLPTKISTK	TPNASNQTDS
ELYAFECPVY	QTPERSRILA	TTGLPTNFLT	SVYLSTKKPP	SHWITMRVAL
LCEKNEK

Funkcija

Dineini su proteinski kompleksi motornih proteina, povezanih s mikrotubulama, sastavljeni od nekoliko teških, lahkih i srednjeteških lanaca. Identificirane su dvije glavne klase dineina: aksonski i citoplazmatski. DNAH14 je aksonemski teški lanac dineina (DHC) (Vaughan et al., 1996 PubMed 8812413]).^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185842 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047369 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Dynein, axonemal, heavy chain 14".
^ "UniProt, Q0VDD8" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (august 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185842 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047369 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Dynein, axonemal, heavy chain 14".

[UniProt-6] "UniProt, Q0VDD8" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[7] Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (august 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

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