WBP4
WW domen-vezujući protein 4 je proteinkoji je kod ljudi kodiran genom WBP4.[5][6]
Ovaj gen kodira domen WW, koji sadrži vezujući protein 4. WW domen predstavlja malu i kompaktnu koptastu strukturu koja stupa u interakciju s prolinom bogatim ligandima. Ovaj kodirani protein je općeniti splajsosomni protein koji može imati ulogu u unakrsnom premošćivanju U1 i U2 snRNP-ova u splajsosomnom kompleksu A.[6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 376 aminokiselina, a molekulska težina 42.507 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MADYWKSQPK | KFCDYCKCWI | ADNRPSVEFH | ERGKNHKENV | AKRISEIKQK | ||||
| SLDKAKEEEK | ASKEFAAMEA | AALKAYQEDL | KRLGLESEIL | EPSITPVTST | ||||
| IPPTSTSNQQ | KEKKEKKKRK | KDPSKGRWVE | GITSEGYHYY | YDLISGASQW | ||||
| EKPEGFQGDL | KKTAVKTVWV | EGLSEDGFTY | YYNTETGESR | WEKPDDFIPH | ||||
| TSDLPSSKVN | ENSLGTLDES | KSSDSHSDSD | GEQEAEEGGV | STETEKPKIK | ||||
| FKEKNKNSDG | GSDPETQKEK | SIQKQNSLGS | NEEKSKTLKK | SNPYGEWQEI | ||||
| KQEVESHEEV | DLELPSTENE | YVSTSEADGG | GEPKVVFKEK | TVTSLGVMAD | ||||
| GVAPVFKKRR | TENGKSRNLR | QRGDDQ |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000120688 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022023 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
- ^ a b "Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)".
- ^ "UniProt, O75554". Pristupljeno 5. 8. 2021.
Dopunska literatura
[uredi | uredi izvor]- Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site". Mol. Cell. 18 (2): 245–51. doi:10.1016/j.molcel.2005.03.018. PMID 15837427.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
- Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains". EMBO J. 15 (5): 1045–54. doi:10.1002/j.1460-2075.1996.tb00442.x. PMC 450002. PMID 8605874.