NUPL1

NUPL1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4JO7, 4JO9, 4JQ5, 5IJN, 5IJO
Identifikatori
Aliasi	NUP58
Vanjski ID-jevi	OMIM: 607615 MGI: 1919094 HomoloGene: 40924 GeneCards: NUP58
Lokacija gena (čovjek)
Hrom.	Hromosom 13 (čovjek)
Kraj	25,365,390 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	60,488,956 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nuclear localization sequence binding; • GO:0005487 structural constituent of nuclear pore;
Ćelijska komponenta	• Jedarna membrana; • nuclear envelope; • membrana; • jedro; • jedrova pora; • GO:0009327 makromolekulani kompleks; • host cell;
Biološki proces	• mRNA transport; • protein heterotetramerization; • protein heterooligomerization; • nucleocytoplasmic transport; • regulation of protein import into nucleus; • protein transport; • GO:0022415 viral process; • protein homooligomerization; • mRNA export from nucleus; • protein import into nucleus; • protein heterotrimerization; • regulation of glycolytic process; • tRNA export from nucleus; • protein sumoylation; • viral transcription; • GO:1905616 regulation of gene silencing by miRNA; • GO:0046795 intracellular transport of virus; • regulation of cellular response to heat;
	Izvori:Amigo / QuickGO
Ortolozi
	9818
	71844
	ENSG00000139496
	ENSMUSG00000114797
	Q9BVL2
	Q8R332
	NM_001008564; NM_001008565; NM_014089; NM_014778
	NM_170591; NM_001362439; NM_001362440
	NP_001008564; NP_054808
	NP_733479; NP_001349368; NP_001349369
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Nukleoporin p58/p45 je protein koji je kod ljudi kodiran genom NUPL1.^[5]^[6]

Ovaj gen kodira člana porodice nukleoporina koji dijeli 87% identiteta sekvence s nukleoporinom p58 pacova. Protein je lokaliziran na jedarnom rubu i sastavni je dio kompleksa jedarnih pora (NPC).

Sve molekule koji ulaze ili izlaze iz jedra difundiraju ili se aktivno transportiraju pomoću NPC -a. Okarakterizirane su alternativne transkripcijske varijante, koje kodiraju različite izoforme.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 599 aminokiselina, a molekulska težina 60.897 Da.^[7].

10	20	30	40	50
MSTGFSFGSG	TLGSTTVAAG	GTSTGGVFSF	GTGASSNPSV	GLNFGNLGST
STPATTSAPS	SGFGTGLFGS	KPATGFTLGG	TNTGIATTIT	TGLTLGTPAT
TSAATTGFSL	GFNKPAASAT	PFALPITSTS	ASGLTLSSAL	TSTPAASTGF
TLNNLGGTTA	TTTTASTGLS	LGGALAGLGG	SLFQSTNTGT	SGLGQNALGL
TLGTTAATST	AGNEGLGGID	FSSSSDKKSD	KTGTRPEDSK	ALKDENLPPV
ICQDVENLQK	FVKEQKQVQE	EISRMSSKAM	LKVQEDIKAL	KQLLSLAANG
IQRNTLNIDK	LKIETAQELK	NAEIALRTQK	TPPGLQHEYA	APADYFRILV
QQFEVQLQQY	RQQIEELENH	LATQANNSHI	TPQDLSMAMQ	KIYQTFVALA
AQLQSIHENV	KVLKEQYLGY	RKMFLGDAVD	VFETRRAEAK	KWQNTPRVTT
GPTPFSTMPN	AAAVAMAATL	TQQQQPATGP	QPSLGVSFGT	PFGSGIGTGL
QSSGLGSSNL	GGFGTSSGFG	CSTTGASTFG	FGTTNKPSGS	LSAGFGSSST
SGFNFSNPGI	TASAGLTFGV	SNPASAGFGT	GGQLLQLKKP	PAGNKRGKR

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139496 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000114797 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
^ ^a ^b "Entrez Gene: NUPL1 nucleoporin like 1".
^ "UniProt, Q9BVL2". Pristupljeno 4. 8. 2021.

Dopunska literatura

Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139496 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000114797 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455477-5] Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

[entrez-6] "Entrez Gene: NUPL1 nucleoporin like 1".

[UniProt-7] "UniProt, Q9BVL2". Pristupljeno 4. 8. 2021.

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