MIB2

MIB2
Identifikatori
Aliasi	MIB2
Vanjski ID-jevi	OMIM: 611141 MGI: 2679684 HomoloGene: 16062 GeneCards: MIB2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	1,630,605 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	155,753,655 bp
Ontologija gena
Molekularna funkcija	• signal transducer activity; • vezivanje iona cinka; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • vezivanje iona metala; • actin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0050372 aktivnost sa transferazom ubikvitina; • aktivnost sa transferazom;
Ćelijska komponenta	• citoplazma; • endozom; • early endosome; • kompleks ubikvitin-ligaze; • citosol;
Biološki proces	• Notch signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • protein ubiquitination; • protein polyubiquitination;
	Izvori:Amigo / QuickGO
Ortolozi
	142678
	76580
	ENSG00000197530
	ENSMUSG00000029060
	Q96AX9
	Q8R516
	NM_001170686; NM_001170687; NM_001170688; NM_001170689; NM_080875
NM_001256107; NM_001256108; NM_001256110; NM_145124; NM_001369161;
	NM_001369162; NM_001369163; NM_001369164; NM_001369165; NM_001369166; NM_001369167; NM_001369168
	NP_001164157; NP_001164158; NP_001164159; NP_001164160; NP_543151
NP_001243036; NP_001243037; NP_660106; NP_001356090; NP_001356091;
	NP_001356092; NP_001356093; NP_001356094; NP_001356095; NP_001356096; NP_001356097
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

E3 ubikvitin-protein ligaza MIB2 jest enzim koji je kod ljudi kodiran genom MIB2 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.013 aminokiselina, a molekulska težina 109.939 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGWKPSEARG	QSQSFQASGL	QPRSLKAARR	ATGRPDRSRA	ARPTMDPSAH
RSRAAPPNMD	PDPQAGVQVG	MRVVRGVDWK	WGQQDGGEGG	VGTVVELGRH
GSPSTPDRTV	VVQWDQGTRT	NYRAGYQGAH	DLLLYDNAQI	GVRHPNIICD
CCKKHGLRGM	RWKCRVCLDY	DLCTQCYMHN	KHELAHAFDR	YETAHSRPVT
LSPRQGLPRI	PLRGIFQGAK	VVRGPDWEWG	SQDGGEGKPG	RVVDIRGWDV
ETGRSVASVT	WADGTTNVYR	VGHKGKVDLK	CVGEAAGGFY	YKDHLPRLGK
PAELQRRVSA	DSQPFQHGDK	VKCLLDTDVL	REMQEGHGGW	NPRMAEFIGQ
TGTVHRITDR	GDVRVQFNHE	TRWTFHPGAL	TKHHSFWVGD	VVRVIGDLDT
VKRLQAGHGE	WTDDMAPALG	RVGKVVKVFG	DGNLRVAVAG	QRWTFSPSCL
VAYRPEEDAN	LDVAERAREN	KSSLSVALDK	LRAQKSDPEH	PGRLVVEVAL
GNAARALDLL	RRRPEQVDTK	NQGRTALQVA	AYLGQVELIR	LLLQARAGVD
LPDDEGNTAL	HYAALGNQPE	ATRVLLSAGC	RADAINSTQS	TALHVAVQRG
FLEVVRALCE	RGCDVNLPDA	HSDTPLHSAI	SAGTGASGIV	EVLTEVPNID
VTATNSQGFT	LLHHASLKGH	ALAVRKILAR	ARQLVDAKKE	DGFTALHLAA
LNNHREVAQI	LIREGRCDVN	VRNRKLQSPL	HLAVQQAHVG	LVPLLVDAGC
SVNAEDEEGD	TALHVALQRH	QLLPLVADGA	GGDPGPLQLL	SRLQASGLPG
SAELTVGAAV	ACFLALEGAD	VSYTNHRGRS	PLDLAAEGRV	LKALQGCAQR
FRERQAGGGA	APGPRQTLGT	PNTVTNLHVG	AAPGPEAAEC	LVCSELALLV
LFSPCQHRTV	CEECARRMKK	CIRCQVVVSK	KLRPDGSEVA	SAAPAPGPPR
QLVEELQSRY	RQMEERITCP	ICIDSHIRLV	FQCGHGACAP	CGSALSACPI
CRQPIRDRIQ	IFV

Interakcije

Pokazalo se da MIB2 (gen) ima interakcije sa aktinom alfa 1.^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197530 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029060 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
^ "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
^ "UniProt, Q96AX9" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)
^ Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

Dopunska literatura

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takeuchi T, Heng HH, Ye CJ, et al. (2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. PMC 1868282. PMID 14507647.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Koo BK, Yoon KJ, Yoo KW, et al. (2005). "Mind bomb-2 is an E3 ligase for Notch ligand". J. Biol. Chem. 280 (23): 22335–42. doi:10.1074/jbc.M501631200. PMID 15824097.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma". DNA Cell Biol. 24 (5): 339–44. doi:10.1089/dna.2005.24.339. PMID 15869411.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma". Am. J. Pathol. 166 (6): 1817–26. doi:10.1016/S0002-9440(10)62491-1. PMC 1602431. PMID 15920166.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Takeuchi T, Adachi Y, Sonobe H, et al. (2006). "A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion". Oncogene. 25 (53): 7059–69. doi:10.1038/sj.onc.1209688. PMID 16715130.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197530 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029060 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12761501-5] Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.

[entrez-6] "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".

[UniProt-7] "UniProt, Q96AX9" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid14507647-8] Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak