LSM5

LSM5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3JCR
Identifikatori
Aliasi	LSM5
Vanjski ID-jevi	OMIM: 607285 MGI: 1913623 HomoloGene: 40833 GeneCards: LSM5
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	32,495,283 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	56,681,695 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• U6 snRNP; • citosol; • Lsm1-7-Pat1 complex; • U4/U6 x U5 tri-snRNP complex; • spliceosomal complex; • jedro; • nukleoplazma; • U2-type precatalytic spliceosome; • Lsm2-8 complex;
Biološki proces	• nuclear-transcribed mRNA catabolic process; • mRNA splicing, via spliceosome; • mRNA processing; • exonucleolytic catabolism of deadenylated mRNA; • Prerada RNK; • response to bacterium;
	Izvori:Amigo / QuickGO
Ortolozi
	23658
	66373
	ENSG00000106355
	ENSMUSG00000091625
	Q9Y4Y9
	P62322
	NM_001130710; NM_001139499; NM_012322
	NM_025520
	NP_001124182; NP_001132971; NP_036454
	NP_079796
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

U6 snRNK-pridruženi Sm-oliki protein LSm5 je protein koji je kod ljudi kodiran genom LSM5.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 91 aminokiselina, а molekulska težina 9.937 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10		20		30		40		50
MAANATTNPS		QLLPLELVDK		CIGSRIHIVM		KSDKEIVGTL		LGFDDFVNMV
LEDVTEFEIT		PEGRRITKLD		QILLNGNNIT		MLVPGGEGPE		V

Funkcija

Sm-liki proteini identifikovani su u različitim organizmima na osnovu komolgije sekvenci sa porodicom Sm proteina (vidi SNRPD2; MIM 601061). Sm-slični proteini sadrže Sm motiv sekvence, koji se sastoji od dvije regije odvojene poveznicom promjenjive dužine, koja se savija kao petlja. Smatra se da proteini slični Sm tvore stabilne heteromer u česticama tri-snRNP, koje su važne za preradu pre-iRNK (prema OMIMu)^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106355 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091625 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
^ Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726 (neaktivno 31. 5. 2021). PMC 1370355. PMID 12515382.CS1 održavanje: DOI nije aktivan od 2021 (link)
^ ^a ^b "Entrez Gene: LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
^ "UniProt, Q9Y4Y9" (jezik: engleski). Pristupljeno 26. 9. 2021.

Dopunska literatura

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
Achsel T, Brahms H, Kastner B, et al. (1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106355 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000091625 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10369684-5] Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.

[pmid12515382-6] Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726 (neaktivno 31. 5. 2021). PMC 1370355. PMID 12515382.CS1 održavanje: DOI nije aktivan od 2021 (link)

[entrez-7] "Entrez Gene: LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

[UniProt-8] "UniProt, Q9Y4Y9" (jezik: engleski). Pristupljeno 26. 9. 2021.

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