CAMTA1

CAMTA1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2CXK
Identifikatori
Aliasi	CAMTA1
Vanjski ID-jevi	OMIM: 611501 MGI: 2140230 HomoloGene: 18942 GeneCards: CAMTA1
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	151,861,876 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• sequence-specific DNA binding; • vezivanje sa DNK; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • Jedarce; • citoplazma; • citosol;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • neuromuscular process controlling balance; • transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • positive regulation of protein dephosphorylation; • positive regulation of calcineurin-NFAT signaling cascade;
	Izvori:Amigo / QuickGO
Ortolozi
	23261
	100072
	ENSG00000171735
	ENSMUSG00000014592
	Q9Y6Y1
	A2A891
	NM_001195563; NM_001242701; NM_015215
	NM_001081557; NM_001166021; NM_001195565
NP_001182492; NP_001229630; NP_056030; NP_001336537; NP_001336538;
	NP_001336539; NP_001336541; NP_001336542; NP_001336543; NP_001336544; NP_001336545; NP_001336546; NP_001336547; NP_001336548; NP_001336549; NP_001336550; NP_001336551; NP_001336552; NP_001336553; NP_001336554; NP_001336555; NP_001336556
	NP_001075026; NP_001182494
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kalmodulin-vezujući transkripcijski aktivator 1 jest protein koji je kod ljudi kodiran genom CAMTA1 sa hromosoma 1.^[4]^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.673 aminokiselina, a molekulska težina 183.672 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MWRAEGKWLP	KTSRKSVSQS	VFCGTSTYCV	LNTVPPIEDD	HGNSNSSHVK
IFLPKKLLEC	LPKCSSLPKE	RHRWNTNEEI	AAYLITFEKH	EEWLTTSPKT
RPQNGSMILY	NRKKVKYRKD	GYCWKKRKDG	KTTREDHMKL	KVQGVECLYG
CYVHSSIIPT	FHRRCYWLLQ	NPDIVLVHYL	NVPAIEDCGK	PCGPILCSIN
TDKKEWAKWT	KEELIGQLKP	MFHGIKWTCS	NGNSSSGFSV	EQLVQQILDS
HQTKPQPRTH	NCLCTGSLGA	GGSVHHKCNS	AKHRIISPKV	EPRTGGYGSH
SEVQHNDVSE	GKHEHSHSKG	SSREKRNGKV	AKPVLLHQSS	TEVSSTNQVE
VPDTTQSSPV	SISSGLNSDP	DMVDSPVVTG	VSGMAVASVM	GSLSQSATVF
MSEVTNEAVY	TMSPTAGPNH	HLLSPDASQG	LVLAVSSDGH	KFAFPTTGSS
ESLSMLPTNV	SEELVLSTTL	DGGRKIPETT	MNFDPDCFLN	NPKQGQTYGG
GGLKAEMVSS	NIRHSPPGER	SFSFTTVLTK	EIKTEDTSFE	QQMAKEAYSS
SAAAVAASSL	TLTAGSSLLP	SGGGLSPSTT	LEQMDFSAID	SNKDYTSSFS
QTGHSPHIHQ	TPSPSFFLQD	ASKPLPVEQN	THSSLSDSGG	TFVMPTVKTE
ASSQTSSCSG	HVETRIESTS	SLHLMQFQAN	FQAMTAEGEV	TMETSQAAEG
SEVLLKSGEL	QACSSEHYLQ	PETNGVIRSA	GGVPILPGNV	VQGLYPVAQP
SLGNASNMEL	SLDHFDISFS	NQFSDLINDF	ISVEGGSSTI	YGHQLVSGDS
TALSQSEDGA	RAPFTQAEMC	LPCCSPQQGS	LQLSSSEGGA	STMAYMHVAE
VVSAASAQGT	LGMLQQSGRV	FMVTDYSPEW	SYPEGGVKVL	ITGPWQEASN
NYSCLFDQIS	VPASLIQPGV	LRCYCPAHDT	GLVTLQVAFN	NQIISNSVVF
EYKARALPTL	PSSQHDWLSL	DDNQFRMSIL	ERLEQMERRM	AEMTGSQQHK
QASGGGSSGG	GSGSGNGGSQ	AQCASGTGAL	GSCFESRVVV	VCEKMMSRAC
WAKSKHLIHS	KTFRGMTLLH	LAAAQGYATL	IQTLIKWRTK	HADSIDLELE
VDPLNVDHFS	CTPLMWACAL	GHLEAAVVLY	KWDRRAISIP	DSLGRLPLGI
ARSRGHVKLA	ECLEHLQRDE	QAQLGQNPRI	HCPASEEPST	ESWMAQWHSE
AISSPEIPKG	VTVIASTNPE	LRRPRSEPSN	YYSSESHKDY	PAPKKHKLNP
EYFQTRQEKL	LPTALSLEEP	NIRKQSPSSK	QSVPETLSPS	EGVRDFSREL
SPPTPETAAF	QASGSQPVGK	WNSKDLYIGV	STVQVTGNPK	GTSVGKEAAP
SQVRPREPMS	VLMMANREVV	NTELGSYRDS	AENEECGQPM	DDIQVNMMTL
AEHIIEATPD	RIKQENFVPM	ESSGLERTDP	ATISSTMSWL	ASYLADADCL
PSAAQIRSAY	NEPLTPSSNT	SLSPVGSPVS	EIAFEKPNLP	SAADWSEFLS
ASTSEKVENE	FAQLTLSDHE	QRELYEAARL	VQTAFRKYKG	RPLREQQEVA
AAVIQRCYRK	YKQYALYKKM	TQAAILIQSK	FRSYYEQKKF	QQSRRAAVLI
QKYYRSYKKC	GKRRQARRTA	VIVQQKLRSS	LLTKKQDQAA	RKIMRFLRRC
RHSPLVDHRL	YKRSERIEKG	QGT

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014592 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bouche N, Scharlat A, Snedden W, Bouchez D, Fromm H (Jun 2002). "A novel family of calmodulin-binding transcription activators in multicellular organisms". Journal of Biological Chemistry. 277 (24): 21851–61. doi:10.1074/jbc.M200268200. PMID 11925432. S2CID 9090244.
^ "Entrez Gene: CAMTA1 calmodulin binding transcription activator 1".
^ "UniProt, Q9Y6Y1" (jezik: engleski). Pristupljeno 22. 11. 2021.

Dopunska literatura

Katoh M, Katoh M (2004). "Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23". International Journal of Oncology. 23 (4): 1219–24. doi:10.3892/ijo.23.4.1219. PMID 12964007.
Nakatani K, Nishioka J, Itakura T, et al. (2004). "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells". Int. J. Oncol. 24 (6): 1407–12. doi:10.3892/ijo.24.6.1407 (neaktivno 31. 10. 2021). PMID 15138581.CS1 održavanje: DOI nije aktivan od 2021 (link)
Barbashina V, Salazar P, Holland EC, et al. (2005). "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene". Clinical Cancer Research. 11 (3): 1119–28. PMID 15709179.
Henrich KO, Claas A, Praml C, et al. (2007). "Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma". European Journal of Cancer. 43 (3): 607–16. doi:10.1016/j.ejca.2006.09.023. PMID 17222547.
Huentelman MJ, Papassotiropoulos A, Craig DW, et al. (2007). "Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance" (PDF). Human Molecular Genetics. 16 (12): 1469–77. doi:10.1093/hmg/ddm097. PMID 17470457.

Vanjski linkovi

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000014592 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11925432-4] Bouche N, Scharlat A, Snedden W, Bouchez D, Fromm H (Jun 2002). "A novel family of calmodulin-binding transcription activators in multicellular organisms". Journal of Biological Chemistry. 277 (24): 21851–61. doi:10.1074/jbc.M200268200. PMID 11925432. S2CID 9090244.

[entrez-5] "Entrez Gene: CAMTA1 calmodulin binding transcription activator 1".

[UniProt-6] "UniProt, Q9Y6Y1" (jezik: engleski). Pristupljeno 22. 11. 2021.

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