Chokepoint Reaction Finder

By default, all metabolic reactions from this organism will be considered as possible chokepoints. The selection buttons below cause certain reactions to be excluded from the set of computed chokepoints based on their suitability as anti-microbial drug targets.

Include all eligible reactions (based on other selections) as potential chokepoints
Exclude reactions found in human to minimize side-effects on human biology
Include all eligible reactions (based on other selections) as potential chokepoints
Exclude reactions catalyzed by more than one enzyme in this organism (the organism has one or more backup enzymes)
Include all eligible reactions (based on other selections) as potential chokepoints
Include only those reactions that are found in multiple pathways in this organism (such reactions may have a stronger disruptive effect)
Definition: A chokepoint reaction is a reaction that is either the unique consumer of a given metabolite (the only reaction consuming that metabolite), or is the unique producer of a metabolite. That metabolite must have at least one reaction that consumes it and at least one reaction that produces it (in other words, the metabolite must not be a dead-end). In theory, chokepoint reactions make good drug targets because disabling that reaction disrupts the only path to or from a metabolite.

The definition of a chokepoint used here was derived from:

Yeh:Yeh I, Hanekamp T, Tsoka S, Karp P, Altman R "Computational analysis of Plasmodium falciparum metabolism: Organizing genomic information to facilitate drug discovery." PMID: 15078855

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