TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. (Q47786161)

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13 November 2019

review article

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title

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads (English)

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13 November 2019

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13 November 2019

A Hata

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13 November 2019

Y Shi

series ordinal

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13 November 2019

publication date

1 June 1998

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Trends in Molecular Medicine

13 November 2019

published in

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13 November 2019

volume

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13 November 2019

issue

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13 November 2019

page(s)

257-262

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TGF-beta signal transduction

13 November 2019

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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Daughters against dpp modulates dpp organizing activity in Drosophila wing development

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Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

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Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

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Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

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A transcriptional partner for MAD proteins in TGF-beta signalling

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A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

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A structural basis for mutational inactivation of the tumour suppressor Smad4

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A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

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Mad-related genes in the human

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7 January 2021

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679244%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

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