The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy (Q33683197)

28 July 2017

title

The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy (English)

1 reference

28 July 2017

Richard D Semba

1 reference

28 July 2017

Hu Huang

1 reference

28 July 2017

Gerard A Lutty

series ordinal

1 reference

28 July 2017

Jennifer E Van Eyk

series ordinal

1 reference

28 July 2017

Gerald W Hart

series ordinal

1 reference

28 July 2017

language of work or name

1 reference

19 February 2014

1 reference

Proteomics - Clinical Applications

28 July 2017

published in

1 reference

28 July 2017

1 reference

28 July 2017

issue

3-4

1 reference

28 July 2017

page(s)

218-231

1 reference

Retinal O-linked N-acetylglucosamine protein modifications: implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy

28 July 2017

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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O-GlcNAc Modification of NFκB p65 Inhibits TNF-α-Induced Inflammatory Mediator Expression in Rat Aortic Smooth Muscle Cells

28 July 2018

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A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome

28 July 2018

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O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells

28 July 2018

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28 July 2018

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28 July 2018

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TNFα Is Required for Late BRB Breakdown in Diabetic Retinopathy, and Its Inhibition Prevents Leukostasis and Protects Vessels and Neurons from Apoptosis

28 July 2018

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Targeted in vivo O-GlcNAc sensors reveal discrete compartment-specific dynamics during signal transduction

28 July 2018

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New therapeutic approaches in the treatment of diabetic keratopathy: a review

28 July 2018

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Human OGA binds substrates in a conserved peptide recognition groove

28 July 2018

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Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

28 July 2018

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Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice

28 July 2018

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O-GlcNAcylation of tubulin inhibits its polymerization.

28 July 2018

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Effects of medical therapies on retinopathy progression in type 2 diabetes

28 July 2018

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28 July 2018

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28 July 2018

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Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes

28 July 2018

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Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc

28 July 2018

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Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis

28 July 2018

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Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes

28 July 2018

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28 July 2018

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Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

28 July 2018

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Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry

28 July 2018

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28 July 2018

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TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations

28 July 2018

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28 July 2018

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Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts

28 July 2018

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28 July 2018

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28 July 2018

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A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose

28 July 2018

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28 July 2018

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O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels

28 July 2018

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Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

28 July 2018

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Cell signaling, the essential role of O-GlcNAc!

28 July 2018

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O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry

28 July 2018

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28 July 2018

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Hexosamines, insulin resistance, and the complications of diabetes: current status

28 July 2018

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O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes

28 July 2018

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Selective decrease of membrane-associated PKC-alpha and PKC-epsilon in response to elevated intracellular O-GlcNAc levels in transformed human glial cells

28 July 2018

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Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats

28 July 2018

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Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells

28 July 2018

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Corneal nerves: structure, contents and function

28 July 2018

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Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications

28 July 2018

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Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

28 July 2018

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Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens

28 July 2018

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Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase

28 July 2018

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Role of the hexosamine biosynthetic pathway in diabetic nephropathy

28 July 2018

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Expressed protein ligation: a general method for protein engineering

28 July 2018

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Role of the glucosamine pathway in fat-induced insulin resistance

28 July 2018

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The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

28 July 2018

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High molecular weight microtubule-associated proteins contain O-linked-N-acetylglucosamine

28 July 2018

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Dynamic O-GlcNAcylation of the small heat shock protein alpha B-crystallin

28 July 2018

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Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM.

28 July 2018

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Receptor-Mediated Toxicity to Pericytes of Advanced Glycosylation End Products: A Possible Mechanism of Pericyte Loss in Diabetic Microangiopathy

28 July 2018

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In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

28 July 2018

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Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamine

28 July 2018

1 reference

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The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.

28 July 2018

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A general method for site-specific incorporation of unnatural amino acids into proteins.

28 July 2018

1 reference

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Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

28 July 2018

1 reference

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Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine

28 July 2018

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Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.

28 July 2018

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A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2.

21 January 2018

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Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study

21 January 2018

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Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial

21 January 2018

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Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials

21 January 2018

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Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity

21 January 2018

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Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

21 January 2018

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Suppression of GLUT1; a new strategy to prevent diabetic complications

21 January 2018

1 reference

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Post-transcriptional regulation of vascular endothelial growth factor by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Computational identification of interplay between phosphorylation and O-β-glycosylation of human occludin as potential mechanism to impair hepatitis C virus entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Posttranslational modifications on protein kinase c isozymes. Effects of epinephrine and phorbol esters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Plasma kallikrein and diabetic macular edema

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Advanced glycation endproduct induces ROS accumulation, apoptosis, MAP kinase activation and nuclear O-GlcNAcylation in human cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Alterations to the Blood–Retinal Barrier in Diabetes: Cytokines and Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

The Ins2Akita mouse as a model of early retinal complications in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

The Human Eye Proteome Project: perspectives on an emerging proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Evidence of O-linked N-acetylglucosamine in diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Discovery of O-GlcNAc transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Substrate and product analogues as human O-GlcNAc transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Alloxan: history and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Impact of O-GlcNAc on cardioprotection by remote ischaemic preconditioning in non-diabetic and diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

Application of phosphorylation site-specific antibodies to measure nuclear receptor signaling: characterization of novel phosphoantibodies for estrogen receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201300076

O-GlcNAcylation of αB-crystallin regulates its stress-induced translocation and cytoprotection.

21 January 2018

1 reference

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Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes. The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus

30 October 2018

1 reference

12 December 2020

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

1 reference

12 December 2020

Class III beta-tubulin in human retinal pigment epithelial cells in culture and in epiretinal membranes

1 reference

12 December 2020

Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure

1 reference

12 December 2020

A Cellular FRET-Based Sensor for β-O-GlcNAc, A Dynamic Carbohydrate Modification Involved in Signaling

1 reference

12 December 2020

TGF-β-stimulated aberrant expression of class III β-tubulin via the ERK signaling pathway in cultured retinal pigment epithelial cells

1 reference

12 December 2020

Detection and Analysis of Proteins Modified by O‐Linked N‐Acetylglucosamine

1 reference

12 December 2020

Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles

1 reference

12 December 2020

Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

1 reference

12 December 2020

Identifiers

DOI

10.1002/PRCA.201300076

1 reference

28 July 2017

1 reference

28 July 2017

1 reference