Intrinsically disordered regions as affinity tuners in protein-DNA interactions (Q37932415)

25 August 2017

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title

Intrinsically disordered regions as affinity tuners in protein-DNA interactions (English)

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25 August 2017

Dana Vuzman

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25 August 2017

Yaakov Levy

series ordinal

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25 August 2017

publication date

15 September 2011

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25 August 2017

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

47-57

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Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

25 August 2017

cites work

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsically disordered protein

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsically unstructured proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsically unstructured proteins and their functions

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

What does it mean to be natively unfolded?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsic disorder in transcription factors

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Function and structure of inherently disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Tight regulation of unstructured proteins: from transcript synthesis to protein degradation

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsically disordered proteins: regulation and disease

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsic Disorder in Ubiquitination Substrates

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsic disorder and protein function

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Sequence complexity of disordered protein

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Role of backbone-solvent interactions in determining conformational equilibria of intrinsically disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Biophysical characterization of intrinsically disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Sequence determinants of compaction in intrinsically disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

From the Cover: Charge interactions can dominate the dimensions of intrinsically disordered proteins.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

To fold or expand—a charged question

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Energy landscape analyses of disordered histone tails reveal special organization of their conformational dynamics

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Comparing models of evolution for ordered and disordered proteins.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

21 January 2018

Evolution and disorder

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https://api.crossref.org/works/10.1039%2FC1MB05273J

The interplay between structure and function in intrinsically unstructured proteins.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Coupling of folding and binding for unstructured proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Close encounters: why unstructured, polymeric domains can increase rates of specific macromolecular association

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Speeding molecular recognition by using the folding funnel: the fly-casting mechanism

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Capillarity theory for the fly-casting mechanism

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Preformed structural elements feature in partner recognition by intrinsically unstructured proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Primary contact sites in intrinsically unstructured proteins: the case of calpastatin and microtubule-associated protein 2.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Linear motifs: evolutionary interaction switches.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Local structural disorder imparts plasticity on linear motifs.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Dynamic protein–DNA recognition: beyond what can be seen

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Coupling of local folding to site-specific binding of proteins to DNA

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: basis of binding specificity

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Functional Specificity of a Hox Protein Mediated by the Recognition of Minor Groove Structure

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

The extended arms of DNA-binding domains: a tale of tails

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Forces driving the binding of homeodomains to DNA.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

An end to 40 years of mistakes in DNA-protein association kinetics?

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

How do site-specific DNA-binding proteins find their targets?

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

How to get from A to B: strategies for analysing protein motion on DNA.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Diffusion-controlled macromolecular interactions

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Probing transcription factor dynamics at the single-molecule level in a living cell

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Kinetics of protein-DNA interaction: facilitated target location in sequence-dependent potential

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Spatial effects on the speed and reliability of protein-DNA search

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

The Sequence of the Human Genome

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

DNA search efficiency is modulated by charge composition and distribution in the intrinsically disordered tail

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

What drives proteins into the major or minor grooves of DNA?

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Detecting transient intermediates in macromolecular binding by paramagnetic NMR.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

The effects of intersegmental transfers on target location by proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Quantifying hopping and jumping in facilitated diffusion of DNA-binding proteins.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Binding-induced folding of a natively unstructured transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsically disordered p53 extreme C-terminus binds to S100B(betabeta) through "fly-casting".

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Topology‐based modeling of intrinsically disordered proteins: Balancing intrinsic folding and intermolecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Intrinsically Disordered Proteins in a Physics-Based World

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

The first 30 years of p53: growing ever more complex

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Blinded by the Light: The Growing Complexity of p53

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Regulation of DNA binding of p53 by its C-terminal domain

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

p53 linear diffusion along DNA requires its C terminus

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

A single-molecule characterization of p53 search on DNA

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

p53-Induced DNA bending: the interplay between p53-DNA and p53-p53 interactions

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Allosteric regulation of the transcription factor NFAT1 by multiple phosphorylation sites: a mathematical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Gradual phosphorylation regulates PC4 coactivator function

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Post-translational modification of p53 in tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Covalent and noncovalent modifiers of the p53 protein

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Regulation of p53 responses by post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

The histone tails of the nucleosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Nucleosomes and the chromatin fiber

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Higher-order structure of chromatin and chromosomes

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Structures and interactions of the core histone tail domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Core histone-DNA interactions in sea urchin sperm chromatin. The N-terminal tail of H2B interacts with linker DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Chromatin remodeling enzymes: who's on first?

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Histone acetyltransferases

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

Chromatin disruption and modification

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MB05273J

The language of covalent histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Translating the Histone Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Domain combinations in archaeal, eubacterial and eukaryotic proteomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Thermodynamics of DNA binding of MM17, a 'single chain dimer' of transcription factor MASH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Structure-function-rescue: the diverse nature of common p53 cancer mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Linker length and composition influence the flexibility of Oct-1 DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Intra- and intermolecular translocation of the bi-domain transcription factor Oct1 characterized by liquid crystal and paramagnetic NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Molecular Principles of the Interactions of Disordered Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Facilitated Diffusion of DNA-Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Direct Observation of Enhanced Translocation of a Homeodomain between DNA Cognate Sites by NMR Exchange Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

NMR Studies of Translocation of the Zif268 Protein between Its Target DNA Sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

The Affinity-Enhancing Roles of Flexible Linkers in Two-Domain DNA-Binding Proteins†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

Single-Chain versus Dimeric Protein Folding: Thermodynamic and Kinetic Consequences of Covalent Linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05273J

21 January 2018

Identifiers

DOI

10.1039/C1MB05273J

1 reference

25 August 2017

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