The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (Q36602569)

15 August 2017

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title

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (English)

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15 August 2017

Gudmundsdottir K

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15 August 2017

Ashworth A

series ordinal

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15 August 2017

language of work or name

English

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publication date

1 September 2006

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15 August 2017

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

5864-5874

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A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

The BRC repeats are conserved in mammalian BRCA2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA2 BRC motifs bind RAD51-DNA filaments

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1 required for transcription-coupled repair of oxidative DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Theoretical biology. A robust view of biochemical pathways.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Mechanism of DNA double-strand break repair by non-homologous end joining

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Genome maintenance mechanisms for preventing cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

The role of BRCA1 in the cellular response to chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Proteasome Involvement in the Repair of DNA Double-Strand Breaks

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Initial sequencing and analysis of the human genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Deficiency in BRCA2 leads to increase in non-conservative homologous recombination.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

DSS1 is required for the stability of BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Mechanism and regulation of human non-homologous DNA end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Brca1 controls homology-directed DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1 regulates p53-dependent gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Involvement of Brca2 in DNA repair

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Direct DNA binding by Brca1

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Pathways of DNA double-strand break repair during the mammalian cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Structure and function of the double-strand break repair machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA2-dependent and independent formation of RAD51 nuclear foci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Hallmarks of 'BRCAness' in sporadic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Regulation and mechanisms of mammalian double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Chromosomal stability and the DNA double-stranded break connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Molecular views of recombination proteins and their control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

Chromosomal translocation mechanisms at intronic alu elements in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

7 January 2021

The BRCA2-Interacting Protein DSS1 Is Vital for DNA Repair, Recombination, and Genome Stability in Ustilago maydis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

7 January 2021

Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

7 January 2021

Conserved domains in the chicken homologue of BRCA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

7 January 2021

BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209874

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209874

1 reference

15 August 2017

1 reference