Dying for a cause: invertebrate genetics takes on human neurodegeneration (Q35074847)

6 August 2017

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title

Dying for a cause: invertebrate genetics takes on human neurodegeneration (English)

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6 August 2017

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Monica Driscoll

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6 August 2017

Beate Gerstbrein

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6 August 2017

publication date

1 March 2003

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6 August 2017

published in

Nature Reviews Genetics

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

181-194

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Of flies and men--studying human disease in Drosophila

6 August 2017

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A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans

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The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types

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Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration

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Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis

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Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene

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A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

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Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene

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Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

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Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

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Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease

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Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

21 January 2018

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Interaction of intracellular beta amyloid peptide with chaperone proteins

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

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Cloning and characterization of the Drosophila presenilin homologue

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Isolation and characterization of Drosophila presenilin homolog

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

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A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

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Drosophila nicastrin is essential for the intramembranous cleavage of notch

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

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Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

21 January 2018

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SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production

21 January 2018

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Presenilin is required for proper morphology and function of neurons in C. elegans

21 January 2018

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Parkin and the molecular pathways of Parkinson's disease

21 January 2018

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Neuropathology of synuclein aggregates

21 January 2018

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Parkinsonism proteolysis and proteasomes

21 January 2018

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Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

21 January 2018

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A Drosophila model of Parkinson's disease

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

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Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster

21 January 2018

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Mouse and fly models of neurodegeneration

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Glutamine repeats and neurodegeneration

21 January 2018

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Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

21 January 2018

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Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

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Identification of genes that modify ataxin-1-induced neurodegeneration.

21 January 2018

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Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

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Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

21 January 2018

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Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

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Genetic suppression of polyglutamine toxicity in Drosophila

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Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

21 January 2018

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

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Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

21 January 2018

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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

21 January 2018

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

21 January 2018

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 January 2018

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The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

21 January 2018

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Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity

21 January 2018

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The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1 alpha and Drosophila single-minded

21 January 2018

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The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

21 January 2018

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Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila

21 January 2018

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repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system

21 January 2018

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Defective glia induce neuronal apoptosis in the repo visual system of Drosophila

21 January 2018

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Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster

21 January 2018

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Drosophila as a model to study human brain degenerative diseases.

21 January 2018

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

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Translating cell biology into therapeutic advances in Alzheimer's disease

21 January 2018

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Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

21 January 2018

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Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila

21 January 2018

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Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

21 January 2018

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Analysis of Protein Domain Families in Caenorhabditis elegans

21 January 2018

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Blood Flow Regulation by S-Nitrosohemoglobin in the Physiological Oxygen Gradient

21 January 2018

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The worm in us - Caenorhabditis elegans as a model of human disease

21 January 2018

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In vivo aggregation of beta-amyloid peptide variants

21 January 2018

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C. elegans: a novel pharmacogenetic model to study Parkinson's disease

21 January 2018

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Glutamate release in severe brain ischaemia is mainly by reversed uptake

21 January 2018

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Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila.

31 March 2020

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Gαs-Induced Neurodegeneration inCaenorhabditis elegans

31 March 2020

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Neuropathology of degenerative cell death in Caenorhabditis elegans

31 March 2020

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TheSwiss CheeseMutant Causes Glial Hyperwrapping and Brain Degeneration inDrosophila

31 March 2020

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The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

31 March 2020

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Alzheimer's disease: genes, proteins, and therapy

31 March 2020

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Neuropathological classification of Huntington's disease

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRG1018

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6 August 2017

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