Engineering cellular microenvironments to improve cell-based drug testing (Q34669632)

3 August 2017

1 reference

title

Engineering cellular microenvironments to improve cell-based drug testing (English)

1 reference

3 August 2017

Kiran Bhadriraju

1 reference

3 August 2017

Christopher S Chen

series ordinal

1 reference

3 August 2017

publication date

1 June 2002

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

3 August 2017

page(s)

612-620

1 reference

Proteomics: applications and opportunities in preclinical drug development

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Drug screening--beyond the bottleneck

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Drug discovery and target validation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Drug discovery--an operating model for a new era

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

HTS in the new millennium: the role of pharmacology and flexibility

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Real-time molecular and cellular analysis: the new frontier of drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Unravelling novel intracellular pathways in cell-based assays

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

In-vivo and in-vitro models of type 2 diabetes in pharmaceutical drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Approaches for the development of cell-based in vitro methods for contact sensitization

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Development and intralaboratory evaluation of an in vitro human cell-based test to aid ocular irritancy assessments

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

In vitro prediction of gastrointestinal absorption and bioavailability: an experts' meeting report.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Molecules for the millennium: how will they look? New drug discovery year 2000.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Evolution of anticancer drug discovery and the role of cell-based screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Virtual screening of intestinal drug permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Switching from differentiation to growth in hepatocytes: control by extracellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Geometric control of cell life and death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

The transcriptional program in the response of human fibroblasts to serum

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Extracellular matrix alters PDGF regulation of fibroblast integrins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Extracellular matrix and wound healing.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Stretching is good for a cell

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Cell adhesion: the molecular basis of tissue architecture and morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Engineering cell shape and function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Angiogenesis: new targets for the development of anticancer chemotherapies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Lumen formation during angiogenesis in vitro involves phagocytic activity, formation and secretion of vacuoles, cell death, and capillary tube remodelling by different populations of endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Extracorporeal tissue engineered liver-assist devices.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Extended primary culture of human hepatocytes in a collagen gel sandwich system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Structural polarity and functional bile canaliculi in rat hepatocyte spheroids

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Micropatterned surfaces for control of cell shape, position, and function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Microstamp patterns of biomolecules for high-resolution neuronal networks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Microcontact printing for precise control of nerve cell growth in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Engineering gene expression and protein synthesis by modulation of nuclear shape

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Photopatterning of antibodies on biosensors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Formation of Microscale Gradients of Protein Using Heterobifunctional Photolinkers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Turning On Cell Migration with Electroactive Substrates We are grateful for support of this work by DARPA and the National Institute of Health (GM 54621). This work used facilities of the MRSEC supported by the National Science Foundation (DMR-98085

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Using electroactive substrates to pattern the attachment of two different cell populations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Microfluidics--downsizing large-scale biology

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

Patterning cells and their environments using multiple laminar fluid flows in capillary networks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902273-0

7 January 2021

10.1016/S1359-6446(02)02273-0

Identifiers

DOI

1 reference

3 August 2017

1 reference