A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor (Q34403975)

1 August 2017

title

A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor (English)

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1 August 2017

main subject

phase I clinical trial

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1 August 2017

Harry L Malech

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Katherine R Calvo

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Philip M Murphy

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1 August 2017

Sandra Anaya-O'Brien

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1 August 2017

Stefania Pittaluga

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1 August 2017

Qian Liu

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1 August 2017

Daniel Velez

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1 August 2017

Lizbeeth Lopez

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1 August 2017

Jean Ulrick

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1 August 2017

Nana Kwatemaa

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1 August 2017

Judy Starling

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1 August 2017

Thomas A Fleisher

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1 August 2017

Debra A Long Priel

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1 August 2017

Melissa A Merideth

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1 August 2017

Robert L Giuntoli

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1 August 2017

Moses O Evbuomwan

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1 August 2017

Patricia Littel

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1 August 2017

Martha M Marquesen

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1 August 2017

Dianne Hilligoss

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1 August 2017

Rosamma DeCastro

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1 August 2017

George J Grimes

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1 August 2017

Samuel T Hwang

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Pamela Stratton

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Edward W Cowen

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Douglas B Kuhns

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1 August 2017

language of work or name

English

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publication date

12 February 2014

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1 August 2017

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1 August 2017

volume

123

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1 August 2017

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1 August 2017

page(s)

2308-2316

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Incidence, clinical spectrum, risk factors and impact of HIV-associated immune reconstitution inflammatory syndrome in South Africa

1 August 2017

cites work

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Description and outcome of a cohort of 8 patients with WHIM syndrome from the French Severe Chronic Neutropenia Registry

6 July 2018

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A review on CXCR4/CXCL12 axis in oncology: no place to hide.

6 July 2018

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The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

6 July 2018

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The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome

6 July 2018

1 reference

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AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome

6 July 2018

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Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

6 July 2018

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Oligoclonality, impaired class switch and B-cell memory responses in WHIM syndrome

6 July 2018

1 reference

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Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor

6 July 2018

1 reference

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Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization

6 July 2018

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WHIM syndrome: congenital immune deficiency disease

6 July 2018

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WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4

6 July 2018

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Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

6 July 2018

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Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

6 July 2018

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Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease

6 July 2018

1 reference

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Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

6 July 2018

1 reference

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

6 July 2018

1 reference

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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

6 July 2018

1 reference

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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

6 July 2018

1 reference

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A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia.

6 July 2018

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A new familial immunodeficiency disorder characterized by severe neutropenia, a defective marrow release mechanism, and hypogammaglobulinemia

6 July 2018

1 reference

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Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells

6 July 2018

1 reference

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Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantatio

27 October 2018

1 reference

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Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow.

27 October 2018

1 reference

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Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist

27 October 2018

1 reference

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Intravenous immunoglobulin replacement prevents severe and lower respiratory tract infections, but not upper respiratory tract and non-respiratory infections in common variable immune deficiency

27 October 2018

1 reference

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Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells

27 October 2018

1 reference

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Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

27 October 2018

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Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome

27 October 2018

1 reference

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CHRONIC IDIOPATHIC GRANULOCYTOPENIA.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983611

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

27 October 2018

1 reference

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Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

9 December 2018

1 reference

12 December 2020

Defect of plasmacytoid dendritic cells in warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome patients

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12 December 2020

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

1 reference

12 December 2020

A pivotal role for CXCL12 signaling in HPV-mediated transformation of keratinocytes: clues to understanding HPV-pathogenesis in WHIM syndrome

1 reference

12 December 2020

"MYELOKATHEXIS"--A NEW FORM OF CHRONIC GRANULOCYTOPENIA. REPORT OF A CASE

1 reference

12 December 2020

10.1182/BLOOD-2013-09-527226

Identifiers

DOI

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1 August 2017

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1 August 2017

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