Single-cell sequencing-based technologies will revolutionize whole-organism science (Q34360540)

1 August 2017

title

Single-cell sequencing-based technologies will revolutionize whole-organism science (English)

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1 August 2017

Sten Linnarsson

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1 August 2017

Ehud Shapiro

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1 August 2017

Tamir Biezuner

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1 August 2017

publication date

30 July 2013

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1 August 2017

published in

Nature Reviews Genetics

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

618-630

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Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study

1 August 2017

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Single-cell dissection of transcriptional heterogeneity in human colon tumors

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The future is now: single-cell genomics of bacteria and archaea

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31 March 2020

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Droplet microfluidics for high-throughput biological assays

31 March 2020

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Whole-genome molecular haplotyping of single cells

31 March 2020

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Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm

31 March 2020

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31 March 2020

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31 March 2020

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Adult neurogenesis in the mammalian brain: significant answers and significant questions

31 March 2020

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Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both?

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Reconstruction of cell lineage trees in mice

31 March 2020

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Muscle-bound primordial stem cells give rise to myofiber-associated myogenic and non-myogenic progenitors

31 March 2020

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Characterizing and measuring bias in sequence data

31 March 2020

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Metastasis results from preexisting variant cells within a malignant tumor

31 March 2020

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Tumor self-seeding by circulating cancer cells

31 March 2020

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Critical determinants of metastasis

31 March 2020

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31 March 2020

Here, there, everywhere?

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The therapeutic promise of the cancer stem cell concept

31 March 2020

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Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis

31 March 2020

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A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

31 March 2020

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Target for cancer therapy: proliferating cells or stem cells

31 March 2020

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Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor

31 March 2020

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Genetic variegation of clonal architecture and propagating cells in leukaemia

31 March 2020

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Genome-wide copy number analysis of single cells.

31 March 2020

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Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm

31 March 2020

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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

31 March 2020

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

31 March 2020

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The life history of 21 breast cancers

31 March 2020

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Whole genome amplification using a degenerate oligonucleotide primer allows hundreds of genotypes to be performed on less than one nanogram of genomic DNA

31 March 2020

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Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells

31 March 2020

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Comprehensive human genome amplification using multiple displacement amplification

31 March 2020

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Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing

31 March 2020

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Whole genome amplification from single cells in preimplantation genetic diagnosis and prenatal diagnosis

31 March 2020

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Phylogenetic analysis of developmental and postnatal mouse cell lineages.

31 March 2020

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Monitoring the dynamics of primary T cell activation and differentiation using long term live cell imaging in microwell arrays

31 March 2020

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Single-molecule DNA sequencing of a viral genome

31 March 2020

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Real-time DNA sequencing from single polymerase molecules

31 March 2020

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A window into third-generation sequencing

31 March 2020

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Perspectives and challenges of emerging single-molecule DNA sequencing technologies

31 March 2020

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Targeted capture and massively parallel sequencing of 12 human exomes

31 March 2020

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Exome sequencing: the sweet spot before whole genomes

31 March 2020

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Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes

31 March 2020

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Comprehensive mutation analysis for congenital muscular dystrophy: a clinical PCR-based enrichment and next-generation sequencing panel

31 March 2020

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Microfluidic amplification as a tool for massive parallel sequencing of the familial hypercholesterolemia genes

31 March 2020

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Microdroplet-based PCR enrichment for large-scale targeted sequencing

31 March 2020

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Multiplex padlock targeted sequencing reveals human hypermutable CpG variations

31 March 2020

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Targeted resequencing of candidate genes using selector probes.

31 March 2020

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Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss

31 March 2020

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The evolution of cell types in animals: emerging principles from molecular studies

31 March 2020

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Human cell type diversity, evolution, development, and classification with special reference to cells derived from the neural crest

31 March 2020

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Visualization of omics data for systems biology

31 March 2020

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Mitochondrial variability as a source of extrinsic cellular noise

31 March 2020

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Stochastic mRNA synthesis in mammalian cells

31 March 2020

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Nature, nurture, or chance: stochastic gene expression and its consequences

31 March 2020

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Molecular live cell bioimaging in stem cell research

31 March 2020

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31 March 2020

Direct RNA sequencing

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A method for counting PCR template molecules with application to next-generation sequencing

31 March 2020

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Counting absolute numbers of molecules using unique molecular identifiers

31 March 2020

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Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes

31 March 2020

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Counting individual DNA molecules by the stochastic attachment of diverse labels

31 March 2020

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Detection and quantification of rare mutations with massively parallel sequencing

31 March 2020

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Analysis of gene expression in single live neurons

31 March 2020

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CEL-Seq: single-cell RNA-Seq by multiplexed linear amplification

31 March 2020

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Combined transcriptome and genome analysis of single micrometastatic cells

31 March 2020

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An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis

31 March 2020

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mRNA-Seq whole-transcriptome analysis of a single cell

31 March 2020

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Molecular cloning, by a novel approach, of a cDNA encoding a putative olfactory protein in the labial palps of the moth Cactoblastis cactorum

31 March 2020

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Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq

31 March 2020

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In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases

31 March 2020

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Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing.

31 March 2020

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Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues

31 March 2020

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Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data

31 March 2020

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Capturing chromosome conformation

31 March 2020

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Robust 4C-seq data analysis to screen for regulatory DNA interactions.

31 March 2020

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Comprehensive mapping of long-range interactions reveals folding principles of the human genome

31 March 2020

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A high-throughput DNA methylation analysis of a single cell

31 March 2020

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Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling

31 March 2020

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Genetic reconstruction of individual colorectal tumor histories

31 March 2020

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Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

31 March 2020

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Investigating stem cells in human colon by using methylation patterns

31 March 2020

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Methylation reveals a niche: stem cell succession in human colon crypts

31 March 2020

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Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis

31 March 2020

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Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum

31 March 2020

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Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.

31 March 2020

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Probing cellular protein complexes using single-molecule pull-down

31 March 2020

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Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution.

31 March 2020

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Detecting antigens by quantitative immuno-PCR.

31 March 2020

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Multiplexed protein detection by proximity ligation for cancer biomarker validation.

31 March 2020

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Toward Clinical Proteomics on a Next-Generation Sequencing Platform

31 March 2020

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A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection.

31 March 2020

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Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

31 March 2020

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Central dogma at the single-molecule level in living cells

31 March 2020

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The embryonic cell lineage of the nematode Caenorhabditis elegans

31 March 2020

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Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

31 March 2020

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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

31 March 2020

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Automated analysis of embryonic gene expression with cellular resolution in C. elegans.

31 March 2020

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Multidimensional regulation of gene expression in the C. elegans embryo

31 March 2020

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High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.

31 March 2020

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Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells.

31 March 2020

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Mutational processes molding the genomes of 21 breast cancers

31 March 2020

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Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis

31 March 2020

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Library-free methylation sequencing with bisulfite padlock probes

31 March 2020

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Alternative isoform regulation in human tissue transcriptomes

31 March 2020

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The transcriptional landscape of the yeast genome defined by RNA sequencing

31 March 2020

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Stem cell transcriptome profiling via massive-scale mRNA sequencing

31 March 2020

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Quartz-Seq: a highly reproducible and sensitive single-cell RNA sequencing method, reveals non-genetic gene-expression heterogeneity

31 March 2020

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Whole-Genome Amplification by Improved Primer Extension Preamplification PCR (I-PEP-PCR)

31 March 2020

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12 December 2020

The stem cell population of the human colon crypt: analysis via methylation patterns

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12 December 2020

Extensive somatic microsatellite mutations in normal human tissue.

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12 December 2020

Single oocyte bisulfite mutagenesis.

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12 December 2020

Estimating cell depth from somatic mutations

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12 December 2020

Identifiers

DOI

10.1038/NRG3542

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Dimensions Publication ID

1 August 2017

1029194837

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