Pre B cell leukemia homeobox 1 (Q21988411)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PBX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

Prep2: cloning and expression of a new prep family member

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Meis Proteins are Major In Vivo DNA Binding Partners for Wild-Type but Not Chimeric Pbx Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

sequence-specific DNA binding

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

14 February 2019

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

1 reference

14 February 2019

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

10 September 2018

PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41778&geneProductId=UniProtKB:P41778

10 September 2018

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41778&geneProductId=UniProtKB:P41778

14 February 2019

PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

protein binding

4 references

14 February 2019

Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Meis Proteins are Major In Vivo DNA Binding Partners for Wild-Type but Not Chimeric Pbx Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

protein heterodimerization activity

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

ISO

cell component

cytoplasm

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Nonmuscle myosin promotes cytoplasmic localization of PBX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

transcription regulator complex

4 references

14 February 2019

Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

nucleus

12 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Nonmuscle myosin promotes cytoplasmic localization of PBX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

A conformational change in PBX1A is necessary for its nuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Meis Proteins are Major In Vivo DNA Binding Partners for Wild-Type but Not Chimeric Pbx Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

nucleoplasm

proximal/distal pattern formation

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

1 reference

14 February 2019

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

1 reference

14 February 2019

negative regulation of neuron differentiation

1 reference

14 February 2019

Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

embryonic organ development

1 reference

14 February 2019

Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

thymus development

1 reference

14 February 2019

Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

sex differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

1 reference

14 February 2019

spleen development

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

adrenal gland development

1 reference

14 February 2019

Pbx1 is essential for adrenal development and urogenital differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41778&geneProductId=UniProtKB:P41778

1 reference

27 February 2018

embryonic skeletal system development

1 reference

14 February 2019

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

1 reference

14 February 2019

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

regulation of cell population proliferation

1 reference

14 February 2019

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

embryonic limb morphogenesis

1 reference

14 February 2019

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

embryonic hemopoiesis

1 reference

14 February 2019

The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

animal organ morphogenesis

1 reference

14 February 2019

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

urogenital system development

1 reference

14 February 2019

Pbx1 is essential for adrenal development and urogenital differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

positive regulation of G2/M transition of mitotic cell cycle

1 reference

14 February 2019

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

regulation of ossification

1 reference

14 February 2019

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

anterior/posterior pattern specification

1 reference

14 February 2019

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

positive regulation of transcription by RNA polymerase II

3 references

14 February 2019

PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

14 February 2019

Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

steroid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

1 reference

14 February 2019

transcription by RNA polymerase II

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41778&geneProductId=UniProtKB:P41778

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778

1 reference

PBX

1 reference

Homeobox, conserved site

1 reference