Genomic instability--an evolving hallmark of cancer (Q28274009)

Genetic instability in colorectal cancers

31 March 2020

1 reference

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

31 March 2020

1 reference

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

31 March 2020

1 reference

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

31 March 2020

1 reference

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

31 March 2020

1 reference

Breast cancer susceptibility: current knowledge and implications for genetic counselling

31 March 2020

1 reference

RecQ helicases: suppressors of tumorigenesis and premature aging.

31 March 2020

1 reference

Cancer in xeroderma pigmentosum and related disorders of DNA repair

31 March 2020

1 reference

Cancer-susceptibility genes. Gatekeepers and caretakers

31 March 2020

1 reference

31 March 2020

Aneuploidy and cancer

1 reference

Mutations of mitotic checkpoint genes in human cancers

31 March 2020

1 reference

Characterization of MAD2B and other mitotic spindle checkpoint genes

31 March 2020

1 reference

Three classes of genes mutated in colorectal cancers with chromosomal instability

31 March 2020

1 reference

An oncogene-induced DNA damage model for cancer development

31 March 2020

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

1 reference

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

1 reference

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

1 reference

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

1 reference

The consensus coding sequences of human breast and colorectal cancers

31 March 2020

1 reference

The genomic landscapes of human breast and colorectal cancers

31 March 2020

1 reference

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

31 March 2020

1 reference

An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

1 reference

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

31 March 2020

1 reference

Somatic mutations affect key pathways in lung adenocarcinoma

31 March 2020

1 reference

Design and analysis issues in genome-wide somatic mutation studies of cancer

31 March 2020

1 reference

Analytical methods for inferring functional effects of single base pair substitutions in human cancers

31 March 2020

1 reference

31 March 2020

Epigenetics in cancer

1 reference

Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders

31 March 2020

1 reference

Genetic instability is not a requirement for tumor development

31 March 2020

1 reference

Genetic instability and darwinian selection in tumours

31 March 2020

1 reference

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

31 March 2020

1 reference

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression

31 March 2020

1 reference

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

31 March 2020

1 reference

Genomic instability in MycER-activated Rat1A-MycER cells

31 March 2020

1 reference

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

31 March 2020

1 reference

Deregulated cyclin E induces chromosome instability

31 March 2020

1 reference

ATM is a target for positive regulation by E2F-1.

31 March 2020

1 reference

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

31 March 2020

1 reference

The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1)

31 March 2020

1 reference

Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation

31 March 2020

1 reference

31 March 2020

Chromosome fragile sites

1 reference

Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

31 March 2020

1 reference

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

31 March 2020

1 reference

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

31 March 2020

1 reference

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

31 March 2020

1 reference

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

31 March 2020

1 reference

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

1 reference

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

31 March 2020

1 reference

Patterns of somatic mutation in human cancer genomes

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Tumor cell metabolism: cancer's Achilles' heel

31 March 2020

1 reference

Principles of cancer therapy: oncogene and non-oncogene addiction

31 March 2020

1 reference

The coordinate regulation of the p53 and mTOR pathways in cells

31 March 2020

1 reference

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

31 March 2020

1 reference

A genetic model for colorectal tumorigenesis

31 March 2020

1 reference

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

31 March 2020

1 reference

Targeted inactivation of p53 in human cells does not result in aneuploidy

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20177397

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutator phenotype may be required for multistage carcinogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20177397