The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins (Q24324729)

positive regulation of GTPase activity

GOA release 2020-03-11

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ORCID Public Data File 2021

GOA release 2020-03-11

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author name string

R Ballester

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D Marchuk

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M Boguski

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A Saulino

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R Letcher

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M Wigler

Autoradiography using storage phosphor technology

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language of work or name

English

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publication date

16 November 1990

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851-9

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cites work

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7 January 2021

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

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Genetic analysis of the role of cAMP in yeast

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Weights for data related by a tree

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[12] One-step gene disruption in yeast

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Production of single-stranded plasmid DNA

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Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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In yeast, RAS proteins are controlling elements of adenylate cyclase.

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7 January 2021

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway

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7 January 2021

Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene

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7 January 2021

Genetic analysis of mammalian GAP expressed in yeast.

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7 January 2021

The neurofibromatosis type 1 gene encodes a protein related to GAP

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7 January 2021

S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein.

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7 January 2021

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

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7 January 2021

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

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7 January 2021

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

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7 January 2021

Basic local alignment search tool

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7 January 2021

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

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7 January 2021

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

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7 January 2021

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

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7 January 2021

Cloning of bovine GAP and its interaction with oncogenic ras p21.

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Suppression of c-ras transformation by GTPase-activating protein

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7 January 2021

Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway.

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7 January 2021

Predictive motifs derived from cytosine methyltransferases

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7 January 2021

Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

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7 January 2021

Physical mapping of a translocation breakpoint in neurofibromatosis

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7 January 2021

Two NF1 translocations map within a 600-kilobase segment of 17q11.2.

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7 January 2021

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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7 January 2021

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

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7 January 2021

Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17

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7 January 2021

Molecular cloning of two types of GAP complementary DNA from human placenta

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7 January 2021

CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae

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7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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7 January 2021

IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.

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7 January 2021

Purification and characterization of human H-ras proteins expressed in Escherichia coli

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7 January 2021

Regulatory function of the Saccharomyces cerevisiae RAS C-terminus

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7 January 2021

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae

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7 January 2021

IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae

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7 January 2021

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7 January 2021