Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis (Q24295251)

Extracellular matrix protein 1

GOA release 2020-03-11

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protein C-terminus binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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Maurizio Mongiat

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Jian Fu

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Rachel Oldershaw

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Robert Greenhalgh

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Allen M Gown

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Renato V Iozzo

Journal of Biological Chemistry

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language of work or name

English

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publication date

9 May 2003

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published in

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volume

278

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issue

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page(s)

17491-9

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cites work

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Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix

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Antibody mapping and tissue localization of globular and cysteine-rich regions of perlecan domain III.

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Interaction of skeletal muscle cells with collagen type IV is mediated by perlecan associated with the cell surface

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Recombinant domain III of perlecan promotes cell attachment through its RGDS sequence

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The C‐Terminal Domain V of Perlecan Promotes β1 Integrin‐Mediated Cell Adhesion, Binds Heparin, Nidogen and Fibulin‐2 and Can be Modified by Glycosaminoglycans

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Perlecan is essential for cartilage and cephalic development

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Perlecan maintains the integrity of cartilage and some basement membranes

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Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.

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Dyssegmental dysplasia, Silverman-Handmaker type: unexpected role of perlecan in cartilage development

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Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice.

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Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia

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Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

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Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

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Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor.

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Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin

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Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

21 January 2018

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Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan

21 January 2018

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Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope

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The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7

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Fibroblast growth factor-binding protein is a novel partner for perlecan protein core

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Alternative splicing of the Endo16 transcript produces differentially expressed mRNAs during sea urchin gastrulation

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Molecular cloning, characterization, and genetic mapping of the cDNA coding for a novel secretory protein of mouse. Demonstration of alternative splicing in skin and cartilage

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Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro

21 January 2018

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Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells

21 January 2018

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Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).

21 January 2018

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Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan

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Two-hybrid analysis reveals multiple direct interactions for thrombospondin 1

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Self-assembly and supramolecular organization of EMILIN

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Type VI Collagen Anchors Endothelial Basement Membranes by Interacting with Type IV Collagen

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Structure and function of laminin LG modules

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Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin

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Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro

21 January 2018

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Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I

21 January 2018

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Vascular cell-derived heparan sulfate shows coupled inhibition of basic fibroblast growth factor binding and mitogenesis in vascular smooth muscle cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M210529200

The role of collagen-derived proteolytic fragments in angiogenesis

21 January 2018

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Distinct antitumor properties of a type IV collagen domain derived from basement membrane

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Angiogenesis in cancer, vascular, rheumatoid and other disease

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The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan

21 January 2018

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Heparan sulfate proteoglycan (perlecan) expression by mouse embryos during acquisition of attachment competence

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Structural basis of glycosaminoglycan modification and of heterotypic interactions of perlecan domain V

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Mammalian tissue distribution of a large heparan sulfate proteoglycan detected by monoclonal antibodies

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