Protein–protein interaction networks articles from across Nature Portfolio

Group A Streptococcus exploits the human fibrinolytic system to promote infection. Here, the authors reveal that the bacterial toxin streptolysin O binds to plasminogen and accelerates its conversion to plasmin, thereby dismantling blood clots and facilitating the spread within the human host.

A study explores how purple bacteria adapt metabolically to cathodic bioelectrochemical conditions. Rhodopseudomonas is found to be the primary electron mediator, enhancing CO2 uptake and PHA accumulation in the consortium.

Experimental and computational studies are paving way for a deeper understanding of the dynamic nature of protein–protein interactions.

Stephen Michnick provides a brief history of protein-fragment complementation — an approach to studying protein–protein interactions in living cells — and discusses advances in its applications and possible future developments.

A method to study G-protein-coupled receptor (GPCR) trafficking has been developed using engineered APEX2 and CRISPR interference screening. The innovative approach reveals a network of proteins coordinated by DNAJC13 that control efficient GPCR sorting into degradative or recycling pathways.

Identifying the protein component of calcium signaling in specific subcellular regions presents considerable challenges. Researchers have now successfully integrated calcium indicators with proximity labeling, enabling the targeting of microdomain-specific calcium signaling.