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Pancreatic cancer is a disease in which malignant cells originate in the pancreatic tissue. Cancer of the exocrine component of the pancreas (adenocarcinomas) represents the majority of pancreatic malignancies. Pancreatic cancer is generally characterized by a poor prognosis.
Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on elucidating the role of the tumour microenvironment and the microbiome in the development and progression of the disease, as well as on the promising potential of artificial intelligence for early diagnosis and outcome prediction.
Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.
Chronic pancreatitis is a risk factor for the development of pancreatic cancer. Here authors report that coxsackievirus and adenovirus receptor (CAR) expression promotes pancreatitis and pancreatic cancer upon enterovirus infections.
Cancer cells rely on macropinocytosis to survive in a nutrient-deprived environment. Here, Lambies et al. identified various members of the cell polarity protein network as essential regulators of macropinocytosis in a context of metabolic stress.
Phenotypic and functional heterogeneity of cancer associated fibroblasts (CAFs) has been reported in pancreatic ductal adenocarcinoma (PDAC). Here the authors show that epithelial MAPK activity promotes myofibroblastic differentiation of CAFs. Furthermore, the epithelial basal-like subtype is associated with a CAF phenotype characterized by elevated MAPK activity and TGF-β signalling, associated with T cell exclusion in PDAC.
Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on elucidating the role of the tumour microenvironment and the microbiome in the development and progression of the disease, as well as on the promising potential of artificial intelligence for early diagnosis and outcome prediction.
Chibaya, DeMarco et al. investigated a combinatorial approach of delivering innate immune agonists and RAS pathway-targeted therapies to remodel the tumour microenvironment and improve PDAC drug response.
