The identification of senescent cells is a long-standing unresolved challenge, owing to their intrinsic heterogeneity and the lack of universal markers. In this Comment, we discuss the recent advent of machine-learning-based approaches to identifying senescent cells by using unbiased, multiparameter morphological assessments, and how these tools can assist future senescence research.
- Imanol Duran
- Cleo L. Bishop
- Ryan Wallis