Depression articles from across Nature Portfolio

Expectations of negative social interactions or low interpersonal self-efficacy are common among people with depression. In this Review, Kirchner et al. integrate the cognitive, social and clinical aspects of expectation formation and describe how they inform the trajectory of depressive symptoms and can boost psychological treatment.

Scientists pinpoint brain circuits linked to either resilience or vulnerability to adversity, which affect a stressed animal’s pursuit of pleasure.

According to a large international study, Internet use among adults 50 or more years of age correlates with reduced depressive symptoms, increased life satisfaction and improved self-reported health.

A device that delivers a small electrical current to the brain has beneficial effects in cases of depression that doesn't respond to drugs or therapy.