Cell signalling articles from across Nature Portfolio

The role of proteases in cartilage degradation and the development of osteoarthritis is undeniable. Despite over two decades of research on protease inhibitors, however, the transition from preclinical promise to clinical success remains elusive, underscoring the urgent need to critically appraise the challenges and limitations inherent in preclinical studies.

Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are found in people with anti-NMDAR encephalitis. Two studies reveal that patient-derived autoantibodies are diverse in their epitope binding and modes of action on the NMDAR, providing insights into the mechanisms behind autoantibody-induced NMDAR hypofunction.

Lin et al. review the phenotypic shifts in vascular smooth muscle and endothelial cells that both drive and result from the chronic inflammation characteristic of atherosclerosis progression. Their review provides insights into potential therapeutic strategies aimed at modulating plaque cell phenotypes to improve clinical outcomes.

Integrins are heterodimeric transmembrane receptors that mediate crucial interactions between cells and extracellular matrix to regulate cellular functions such as intracellular signalling and organization of the actin cytoskeleton. This Review highlights the roles of integrins and integrin-binding proteins in the control of kidney-cell morphology and functions as well as their role in kidney diseases

This study describes ultrastructural changes and cell-specific calcium responses that accompany cytoplasmic bridge formation in legume root cells committed to symbiotic rhizobial infection, with fine-tuning by a calcium-binding annexin.

G-protein coupled receptors (GPCRs) regulate numerous physiological processes and are a prominent therapeutic target. Here, Patel et al. delineate a β-arrestin independent pathway, driven by myosin VI, to shape GPCR trafficking and signaling.

The role of proteases in cartilage degradation and the development of osteoarthritis is undeniable. Despite over two decades of research on protease inhibitors, however, the transition from preclinical promise to clinical success remains elusive, underscoring the urgent need to critically appraise the challenges and limitations inherent in preclinical studies.

A calcium-dependent pathway induces stress granule formation and promotes cell survival following lysosomal damage.

Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are found in people with anti-NMDAR encephalitis. Two studies reveal that patient-derived autoantibodies are diverse in their epitope binding and modes of action on the NMDAR, providing insights into the mechanisms behind autoantibody-induced NMDAR hypofunction.