Cell death articles from across Nature Portfolio

Mutations in the TP53 gene are linked to cancer progression and drug resistance. Here, the authors show that mutant p53 inhibits stress granule formation, leading to increased apoptosis and enhanced sensitivity to the ER stress-inducing chemotherapy drug sorafenib in preclinical models of hepatocellular carcinoma.

This study uncovered how extracellular vesicles carrying gasdermin D pores propagate pyroptosis between cells, exacerbating inflammation.

A study now finds that, after DNA damage, DNA repair by homologous recombination drives non-immunogenic cell death during mitosis. Loss of homologous recombination allows cells to pass through mitosis, but drives interphase death and inflammation. This suggests a dichotomy between immunogenic and non-immunogenic cell-death modes, with biomedical potential.

In 2012, a study revealed a unique form of cell death, termed ferroptosis, that is dependent on iron and unregulated lipid peroxidation. We revisit how this paper changed the trajectory of ferroptosis research from its origins to its current state.