Anxiety articles from across Nature Portfolio

This comprehensive review of amygdala intercalated cells (ITCs) proposes a revised model of ITCs as a highly coordinated system that integrates diverse inputs to orchestrate brain-wide networks and shape behavioral states.

Delineating the neurobiology of pathological anxiety remains challenging. In this Review, Akiki et al. synthesize task-based functional MRI evidence for how vulnerabilities within circuits that mediate acute, distant and sustained threat, reward processing, cognitive control and social processing can lead to its emergence and maintenance.

Using multimodal brain imaging and organ-specific physiological markers from more than 18,000 adult participants of the UK Biobank database, this study reveals integrated pathways that explain the interplay between brain, body, environment and lifestyle, and their collective influence on mental health outcomes.

Ventral striatal activity in individuals with OCD has strong circadian periodicity and high predictability in the severely symptomatic state. After deep brain stimulation, these features decrease substantially in clinical responders but remain raised in non-responders, thus providing a measurable predictor of clinical status.