Allergy articles from across Nature Portfolio

Biochemical and structural studies of the Fc immunoglobulin E receptor show that it exists as a homodimer on mast cell membranes, but dissociates upon IgE binding, exposing immunoreceptor tyrosine-based activation motifs that enable downstream effector activation.

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening severe cutaneous drug reaction mediated by CD8⁺ T cells. Here the authors characterise the immune response in skin samples at the site of tissue damage from patients affected with SJS/TEN and compare this to healthy skin or blister fluid and find populations of CD8⁺ T cell clonotypes expressing cytotoxic mediator molecules.

A γδ T cell–IL-3 signalling axis is defined that controls the allergen responsiveness of cutaneous sensory neurons, leading to evidence for an immune rheostat that governs sensory neuronal responses to allergens on first exposure.

Structural equation models, polygenic risk score analysis of twin data and linkage disequilibrium score regression of GWAS studies indicate genetic architecture of asthma and GERD. Gene-/gene-set analysis revealed six pleiotropic genes.

Transient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-propionic acid, which causes long-lasting mitochondrial damage to lung epithelial cells and increases susceptibility to airway inflammation in adult mice.

CAR T cell technology is being extended beyond the treatment of cancer. New data show that it might also treat allergic asthma, with a single infusion sufficient to prevent pathology for over a year in mice.

In this study, we use a transcriptomic approach as a starting point to explore the heterogeneity of human GATA3-expressing lymphocytes across different tissues and disease contexts. We identify, characterize and functionally validate an abundant progenitor-like memory T cell population with the potential to sustain pathogenic T_H2 cell inflammation.

This study shows how the bacterium Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice.