Adjuvants articles from across Nature Portfolio

Lung tissue-resident memory T cells play critical roles in the response to and protection to subsequent re-exposure and infection with influenza viruses. Here the authors explore vaccine induced lung resident memory T cells and their role in protection to heterosubtypic influenza infection in mice and ferrets.

There is a requirement for improved adjuvants to improve responses to vaccines, including adjuvants that induce Th17 cells. Here, the authors use a MINCLE and TLR9 agonist-based vaccine adjuvant and show induction of Th17 and mucosal immune responses to vaccine recall antigens in mice and non-human primate models of vaccination.

A polymeric nanoparticle adjuvant containing a Toll-like receptor 7 agonist elicits broad protection against viral challenges.

mRNA vaccines such as those used to prevent COVID-19 owe part of their success to methylation that masks immunostimulatory properties of the mRNA, but the immunological mechanisms of adjuvanticity are unclear. Two new studies reveal distinct mechanisms for innate sensing of this hidden adjuvant.

Here, Peter Hotez and colleagues discuss the advantages of using an aluminium-based adjuvant in candidate COVID-19 vaccines.

A vaccine platform developed from a synthetic polymeric glyco-adjuvant and reversibly conjugated to an antigen was shown to target dendritic cells leading to cellular and humoral immune response against malaria.