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Spin valves, consisting of stacked magnetic layers with different magnetization are the essential building block of several distinct spintronic devices. Here, Xu, Liu, Zhao, Lin and coauthors propose that some Kagome magnets can exhibit a self spin-valve effect, and experimentally demonstrate this in the Kagome magnet, TmMn₆Sn₆.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

A process based on perovskite semiconductors is described to downscale micro-LEDs and nano-LEDs to below the conventional size limits, demonstrating average external quantum efficiencies maintained at around 20% across a wide range of pixel lengths.

An analysis of genomic, molecular and neuroanatomical traits across extant primates reveals early divergence in visual and olfactory systems of major primate lineages consistent with lineage-specific shifts in diel activity and dietary niche, providing support for a sensory ‘reallocation’ hypothesis.

This study uses machine learning to design a coolhouse film that regulates temperature and water evaporation to maximize plant photosynthesis efficiency. The film selectively transmits the sunlight needed for photosynthesis, improving crop yield and survival rates in hot, arid regions.

Antipsychotic drugs induce metabolic dysfunction via prodynorphin-expressing ventromedial hypothalamus neuron suppression, which can be mitigated with GLP-2 receptor agonism.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Traditional prosthetic hands have limited degrees of freedom (DOFs) and restricted grasping modes. Here, the authors develop a lightweight (370 g) biomimetic prosthetic hand with 19-DOF driven by shape memory alloy actuators.

A strategy is reported that improves the performance and lifetime of lithium-ion batteries by adding organic Li salt after assembly, which decomposes during cell formation, liberating Li ions and expelling organic ligands as gases.

Light-induced degradation in ambient air hinders the long-term operational stability of tin-lead perovskite solar cells. Here, authors monitor the irreversible phase reconstruction process during perovskite degradation, guiding stability improvements for tin-lead perovskite and tandem solar cells.

Adoptive transfer of genetically or nanoparticle-engineered macrophages has been exploited for cancer therapy. Here the authors report that a subset of cancer cells with upregulated expression of CD133 and programmed death-ligand 1 is associated with resistance to nanoparticle-engineered macrophage-based therapy in melanoma models.

Here, the authors report immunogenicity and safety of AR-MPXV5, a penta-component mRNA vaccine, in naive and simian immunodeficiency virus infected nonhuman primates (NHPs), and demonstrate protection in naïve male NHPs after immunization with two doses of AR-MPXV5.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

The selective and rapid reduction of nitrate at low concentration is technically challenging. Here, the authors report an electrified membrane loaded with Sn pair-atom catalysts that realizes near-complete removal of 10 mg-N/L nitrate and ~100% N₂ selectivity during electro-filtration.

roX (RNA on the X) are crucial for male development in Drosophila. Here, the authors propose a role for roX RNAs in regulating gene expression at specific autosomal loci, working in coordination with Polycomb repressive complexes (PRCs).

The power conversion efficiency of wide-bandgap pure-sulfide kesterite is low. Wang et al. propose annealing in a hydrogen-containing atmosphere and report the underlying mechanism that enables a certified efficiency of 11.4%.

The direct C−H-difluoromethylation of pyridines represents a highly efficient economic way to access azines. However, the direct meta-difluoromethylation of pyridines remains elusive. Here, the authors demonstrate switchable meta- as well as para-C−H difluoromethylation of pyridines through radical processes by using oxazino pyridine intermediates.

Optogenetic tools allowing transcranial neural inhibition in treating seizures are limited. This study demonstrates that noninvasive transcranial optogenetic activation of a highly sensitive K + -conductive channelrhodopsin (HcKCR1-hs) silences neurons and suppresses seizures deep in the brain, alleviating epilepsy symptoms in mouse models, without intracranial surgery.

How GWAS-annotated noncoding SNPs contribute to diabetes remains unclear. Here, the authors report that the noncoding SNP rs6048205 drives stage-specific defects in human pancreatic differentiation and increases diabetes susceptibility in mice.

The mechanisms regulating protein lactylation, a post-translational modification, are not fully understood. Here, the authors discover that Histone deacetylase 6 (HDAC6) acts as the primary lactyltransferase for α-tubulin, regulating microtubule dynamics.

The evolutionary trajectory of avian sex chromosomes may be more intricate than previously understood. In this study, sequencing and analysis of the neo-sex chromosomes and genome of the Crested Ibis suggests a multidirectional evolution of sex chromosomes in core waterbirds.

Optimization of large reaction systems is crucial for chemical research and industrial production, but represents a significant challenge given the heavy experimental load required to find optimal high-yielding conditions. Here, the authors introduce an efficient machine learning tool, RS-Coreset, where they take advantage of deep representation learning techniques to guide an interactive procedure for representing the full reaction space, enabling yield prediction with small-scale data.

Transparent photodetectors based on graphene stacked vertically along the optical axis have shown promising potential for light field reconstruction. Here, the authors develop transparent photodetector arrays and implement a neural network for real-time 3D optical imaging and object tracking.

THz imaging and spectroscopy always request even more efficient components. Here the authors, thanks to a modified photoconductive switch that includes a graphene layer, demonstrate a high-speed photoconductive switch without sacrificing the generated power.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

The delta opioid receptor (δOR) is key in modulating sensation and emotion with a lower risk of drug dependence. Here, authors report cryo-EM structure of δOR and design probes to explore its signaling bias, with insights for drug discovery.

The targeted epigenetic repression of a β₂-microglobulin super-enhancer downregulates the expression of human leucocyte antigens on mesenchymal stromal cells, making the cells suitable for allogeneic cell therapy.

Neovaginas are surgically constructed to correct uterovaginal agenesis in women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Here, in a longitudinal study, the authors characterize the dynamics of neovaginal microbiota assembly, showing resemblance to normal vaginal flora at 6-12 months post-surgery, albeit with a bacterial vaginosis-like structure, and further developed into a structure resembling that of the homeostatic pre-surgery dimple microbiota by 2-4 years post-surgery.

Carboxylesterases catalyze the enantioselective synthesis of chiral carboxylic acids and esters but exhibit limited enantioselectivity, particularly toward ethyl 3-cyclohexene-1- carboxylate (CHCE). Here, the authors establish a high-throughput method to generate a high-quality dataset for carboxylesterase AcEst1 from Acinetobacter sp. JNU9335 using CHCE as the substrate, use it to train a machine learning predictor and design two stereocomplementary mutants to synthesize both enantiomers of chiral CHCE.

Recently, there have been proposals to extend the concept of time crystals to topological order. Here the authors observe a prethermal topologically ordered time crystal on a superconducting quantum processor, where discrete time-translation symmetry breaking manifests for nonlocal rather than local observables.

TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an additional immune evasion function of this bacterially derived virulence factor.

Damaged neural circuits could be improved by generalized BCIs via inputting information into the brains, which is restricted when a large injured cavity caused. Here, the authors construct BCIs mediated by organoid grafts to repair the damaged brain

Catalytic reductive coupling of two electrophiles and one C = C bond is usually performed by two electron transfer metal catalysis. Herein, the authors show a visible light photoredox-catalyzed successive single electron transfer leading to dearomative arylcarboxylation of indoles with CO₂ and generating indoline-3-carboxylic acids.

A variant of structured illumination microscopy called MLS-SIM allows super-resolution imaging of neuronal structures such as spinules, spines and boutons in awake mice.

Molecular ferroelectrics possess switchable spontaneous polarization. Here, the authors show that a molecular ferroelectric crystal demonstrates evident catalytic effects on the synthesis of pharmacologically important substituted quinolines.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The bilayer nickelate La₃Ni₂O₇ was recently shown to be superconducting at high-pressure. Here the authors reveal strong electronic correlations and the opening of a partial gap, providing key information for understanding the nature of the density-wavelike transition at ambient pressure and superconductivity in this compound.

AKT inhibitors synergize with agents that suppress the histone methyltransferase EZH2 and promote robust tumour regression in multiple triple-negative breast cancer models in vivo by triggering an involution-like process.

The gut symbiont Bacteroides fragilis secretes an antimicrobial ubiquitin homologue (BfUbb) that drives intraspecies bacterial competition. Here, the authors identify a highly conserved TonB-dependent transporter SusCD in B. fragilis as the BfUbb transporter and show species-specific antagonism of BfUbb and the BfUbb bound SusCD complex structure, revealing potential therapeutic applications of BfUbb against enterotoxigenic B. fragilis-related diseases.