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The yin–yang codec transcoding algorithm is proposed to improve the practicality and robustness of DNA data storage.

This study reveals how the North Atlantic Oscillation emerged and evolved over 160 million years, highlighting the role of continental drift, land-ocean contrast, and orography in shaping modern atmospheric variability.

The high performance of two-dimensional (2D) channel membranes is generally achieved by preparing ultrathin or forming short channels with less tortuous transport through self-assembly of small flakes. Here, the authors report the construction of vertical channels in graphene oxide membranes based on a substrate template with asymmetric pores demonstrating high flux and metal ion rejection.

Fan and colleagues show that the neurotransmitter GABA signals in intestinal ILC3s to suppress IL-17A production through a regulatory loop that involves suppression of C/EBP-β and induction of Igfb7.

Accurate nonadiabatic molecular dynamics (NAMD) is crucial for studying excited-state dynamics in solids but is computationally expensive. Here, authors use machine learning to enhance the efficiency and accuracy of NAMD simulations in solids.

The PEAK family of pseudokinases is known to play oncogenic roles in poor-prognosis triple negative breast cancer (TNBC). Here this group identifies the role of calcium/calmodulin-dependent protein kinase 2 (CAMK2) in targeting downstream of PEAK1 thereby utilizing RA306 (CAMK2 inhibitor) to effectively attenuate TNBC xenograft growth and block metastasis as well.

Polysubstituted arenes are ubiquitous structural cores in natural products and drugs but their synthesis through programmable arene modification remains a challenge. Now, a palladium- and norbornene-catalysed Catellani-type reaction of aryl ketones, through successive acylation and deacylation, allows the synthesis of polysubstituted arenes.

Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather pathological information for timely interventions. Here, the authors introduce a biodegradable and restorative neural interface for wireless real-time tracking.

Mitochondria is reported to regulate ferroptosis in cancer cells. Here the authors find that mitochondria-localized VSTM2L inhibits the oligomerization of VDAC1 to protect prostate cancer cells against ferroptosis.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

ARF4 GTPase activity is needed for vesicular trafficking for multiple RNA viruses. Blocking ARF4 using specific peptides redirects viral progeny to lysosomal degradation and decreases influenza and Zika virus infection in mice.

This study reports that incorporating non-polar nanodomains into antiferroelectrics greatly enhanced the energy density and efficiency.

Effectively delivering medications to the renal tubule to delay or halt chronic kidney disease progression remains a significant unmet clinical challenge. Here, authors introduce an innovative strategy for renal tubule targeting using biomimetic high-density lipoprotein (bHDL) nanoparticles.

Authors propose an entropy engineering strategy to realize the carrier-phonon decoupling in SrTiO₃-based perovskite thermoelectrics, reducing the lattice thermal conductivity nearly to the amorphous limit and improving the weighted mobility.

Tang, Zhang, Fang, Zhu et al. identify impaired mitochondrial fusion and biogenesis as a key mechanism underlying NOTCH1-associated aortic pathology and show that correcting mitochondrial loss in mutant mice using repurposed drugs teriflunomide or leflunomide slows the progression of aoropathy.

In this work, authors develop a mechano-gated iontronic piezomemristor with temporal-tactile neuromorphic plasticity, enabling bidirectional sensing, learning functions, and biohybrid integration for dynamic tactile neuromodulation.

Tumor-associated macrophages (TAMs) are associated with poor prognosis and low responses to immunotherapy. Here, authors discover that a circular RNA, circPETH, produced by TAMs generates a metabolic reprogramming in hepatocellular carcinoma that promotes metastasis and impairs the activity of cytotoxic CD8 + T cells.

Fan, Shang, Song, Chen et al. identify the Integrator–PP2A complex (INTAC) as a key regulator of cancer cell sensitivity to BET inhibitors through directly interacting with the RACK7–KDM5 complex to orchestrate epigenetic silencing in a catalytic-independent manner.

Difficulties in propagating HRV-C have hindered our understanding of this common respiratory pathogen. Here, authors developed an organoid-based system to reproducibly propagate HRV-C and characterized HRV-C infection in physiologically active respiratory organoids.

The imbalance in structural tension between crystalline materials and surfactant micelles makes the synthesis of crystalline mesoporous metal–organic frameworks (meso-MOFs) challenging. Now single-crystalline meso-MOFs featuring ordered mesopores have been prepared through the assembly of surfactant micelles and subunits of crystalline MOFs—a process co-mediated by strong and weak acids.

The Colorado potato beetle, a major pest of potato crops, displays conspicuous coloration to advertise their toxicity to predators, but the identity of the toxic compounds is unclear. Here, Kang et al. show that the insect releases toxic hydrogen cyanide, which results from the degradation of cyano-compounds produced by commensal bacteria.

Quantum dots with a fine size dispersion offer attractive levels of functional control and manipulation. In this study, Yang et al. report an environmentally friendly top–down synthesis technique, based on laser irradiation of a polydisperse of lead sulphide nanocrystals.

While progress has been made in the catalytic asymmetric synthesis of helicene (-like) molecules, the synthesis of multiple helicenes remains challenging. Herein, the authors report organocatalytic [4 + 2] cycloadditions to achieve double S-shaped quadruple helicene-like molecules with high enantioselectivity.

Protomelission-like macrofossils from the Xiaoshiba Lagerstätte show features characteristic of dasycladalean green alga, suggesting that Protomelission is unlikely to be an early bryozoan.

The Wnt signalling pathway is essential for development and the maintenance of stem cells. Here, the authors reveal how LGR4 and RSPO2 modulate ZNRF3 conformations and assembly heterogeneity, stabilising ZNRF3 in its inactive state to enhance Wnt signalling. These findings offer insights for the development of targeted therapies for Wnt-driven cancers.

Electrochemical CO₂ capture is an emerging field in electrical decarbonization but limiting unwanted side reactivity remains a challenge. Here, authors present an electrochemical capture swing that is decoupled from redox carrier generation, enabling CO₂ capture from O₂-containing gas streams.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

The Hippo signalling pathway is commonly mutated across cancer types. Here, the authors identify 85 loss-of-function missense mutations within Hippo signalling genes and highlight the mechanisms underpinning mutations in MOB1 and NF2.

Wang, Zhang, Zheng et al. demonstrate that tumour cell-derived lymphotoxin-β activates NF-κB2 signalling and CCL2/5 secretion in osteoblasts to promote bone metastasis in breast cancer, which may potentially be targeted with a decoy receptor in vivo.

An optogenetic tool called Opto-OGT has been developed that enables researchers to probe pathways involving modifications with O-linked β-N-acetylglucosamine (O-GlcNAc) such as OGT, mTOR and AMPK signaling with high spatiotemporal precision. The method is based on fusing a photosensitive cryptochrome protein to an O-GlcNAc transferase and enables OGT to be reversibly activated with blue light.

A terahertz phase modulator based on the switchable perturbation resonance in two-dimensional electron gas is demonstrated. Phase manipulation with precision ranging from 2° to 5° is obtained at frequencies in the range from 0.26 to 0.27 THz.

Charge-to-spin conversion is a key theme of spintronics and its realization in topological materials is highly desired. Here, Liu et al. report spatial imaging of current-induced spin accumulation at the edges of Bi₂Se₃ and BiSbTeSe₂ topological insulators.

Benzene is a genotoxic carcinogen with no safe level of exposure. Here, by creating and decorating a structural defect in a metal–organic framework to form MIL-125-Zn, a benzene uptake of 7.63 mmol g^–1 at 1.2 mbar is observed due to binding to Zn(II) sites.

Whole-genome sequencing of 175 Mongolians representing six tribes highlights population-specific genetic architecture and substantial gene flow among northern Eurasian populations, including derived alleles shared by Mongolians and Finns.

The poor conductivity of organic crystals hinders their potential on applications in flexible electronics, wearable devices, and soft robotics. Here, Naumov et al. develop a hybrid organic crystal that shows enhanced electrical conductivity and fast mechanical deformation due to temperature change.

One challenge for spin-based electronics is the controlled and reliable switching of magnetization without magnetic fields. Here, Liu et al investigate a variety of compositions of CoPt, and determine the specific composition to maximize switching performance, potentially simplifying device design.

Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

Mental stress is well known to cause cardiovascular disease. Here, the authors show that an imbalance in RBM24-S181 phosphorylation impairs cardiac translation of APOE, leading to cardiac contractile dysfunction, atrial fibrillation, fibrosis, and sudden death under psychological stress.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Response by mechanical deformation to give actuation is essential in the design of soft robots. Here, the authors demonstrate that combining organic molecular crystals with polymers makes it possible to create materials with susceptible properties to changes in temperature and humidity.