Figure 5 | Scientific Reports

Figure 5

From: Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

Figure 5

Inhibition of protein synthesis rescues both mTORC1 signaling and the ISR during cystine starvation.

HepG2 cells were pretreated with or without CHX (2.5 μM) and then stimulated with or without cystine (100 μM) in the presence or absence of CHX (2.5 μM) for 6 h. Immunoblotting was performed to evaluate the level of phosphorylated and total proteins.

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