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Diabetes

Effect of acute exercise in carriers of TBC1D4 mutation

Nature Metabolism volume 6, pages 2213–2214 (2024)Cite this article

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A nonsense mutation in TBC1D4 has previously been associated with hyperinsulinaemia and increased risk of type 2 diabetes mellitus. A new report shows that carriers have isolated muscle insulin resistance that improves after an acute bout of exercise.

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Fig. 1: Acute exercise improves muscle insulin resistance in carriers of a TBC1D4 mutation.

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Authors and Affiliations

  1. Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA

    Leslie J. Baier & Clifton Bogardus

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  1. Leslie J. Baier
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  2. Clifton Bogardus
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Correspondence to Clifton Bogardus.

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The authors declare no competing interests.

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Baier, L.J., Bogardus, C. Effect of acute exercise in carriers of TBC1D4 mutation. Nat Metab 6, 2213–2214 (2024). https://doi.org/10.1038/s42255-024-01116-6

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