The tumor suppressor p53 is inactivated by genetic mutations in many cancers, except for neuroblastoma. New findings show that this cancer reversibly inhibits p53 through a microRNA, miR-380-5p (pages 1134–1140). Blocking it to restore p53 function may be an attractive therapeutic option for neuroblastomas.
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Eggert, A., Schulte, J. A small kiss of death for cancer. Nat Med 16, 1079–1081 (2010). https://doi.org/10.1038/nm1010-1079
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DOI: https://doi.org/10.1038/nm1010-1079