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TORward AKTually useful mouse models

Nature Medicine volume 10, pages 579–580 (2004)Cite this article

Cancer treatment is evolving from the empirical administration of chemotherapeutics to the precise deployment of molecularly targeted agents. This new paradigm depends on the ability to monitor therapy using molecular signatures of target inhibition in tumor tissue. Genetically engineered mice may prove useful for deriving such signatures, as shown for an analog of the anticancer drug rapamycin (pages 594–601).

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Figure 1: Regulation of the mammalian target of rapamycin (mTOR).

Renee Lucas

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Authors and Affiliations

  1. Departments of Medicine and Molecular and Medical Pharmacology,

    Ingo K Mellinghoff & Charles L Sawyers

  2. Departments of Medicine, Molecular and Medical Pharmacology and Urology, the Molecular Biology Institute, and the Howard Hughes Medical Institute,

    Ingo K Mellinghoff & Charles L Sawyers

  3. David Geffen School of Medicine at UCLA, University of California, Los Angeles, 90095-1678, California, USA

    Ingo K Mellinghoff & Charles L Sawyers

Authors
  1. Ingo K Mellinghoff
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  2. Charles L Sawyers
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Mellinghoff, I., Sawyers, C. TORward AKTually useful mouse models. Nat Med 10, 579–580 (2004). https://doi.org/10.1038/nm0604-579

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