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Rolling back neutrophil adhesion

Nature Immunology volume 11, pages 282–284 (2010)Cite this article

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Neutrophils and other cells secrete the pentraxin PTX3, which promotes innate immunity by binding to pathogens and activating complement. PTX3 can also limit neutrophil recruitment by inhibiting rolling on P-selectin in inflamed venules.

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Figure 1: Model for PTX3's paracrine regulation of neutrophil rolling on P-selectin.

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Authors and Affiliations

  1. Rodger P. McEver is in the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.,

    Rodger P McEver

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  1. Rodger P McEver
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Correspondence to Rodger P McEver.

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Competing interests

R.P.M. is a cofounder of Selexys, a start-up company that is developing antibody-based inhibitors of selectins or selectin ligans.

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McEver, R. Rolling back neutrophil adhesion. Nat Immunol 11, 282–284 (2010). https://doi.org/10.1038/ni0410-282

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