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Lactate transportation is required for lymphocyte activation

Nature Chemical Biology volume 1, pages 356–357 (2005)Cite this article

Identification of the monocarboxylate transporter 1 as a target of a new class of immunosuppressants shows that aerobic glycolysis and lactate release are essential for the proliferation of activated lymphocytes.

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Figure 1: After activation through contact with antigen-presenting cells, T lymphocytes become larger and divide rapidly several times.

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  1. School of Biochemistry & Molecular Biology, Australian National University, Canberra, ACT 0200, Australia

    Stefan Bröer

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  1. Stefan Bröer
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Bröer, S. Lactate transportation is required for lymphocyte activation. Nat Chem Biol 1, 356–357 (2005). https://doi.org/10.1038/nchembio1205-356

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