The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway
Cell Death & Differentiation Open Access 08 October 2022
-
The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
Cell Death Discovery Open Access 14 September 2022
-
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
Cell Death & Disease Open Access 17 August 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
£139.00 per year
only £11.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Vousden, K. H. & Lane, D. P. Nature Rev. Mol. Cell Biol. 8, 275–283 (2007).
Brensaad, K. & Vousden, K. H. Trends Cell Biol. 17, 286–291 (2007).
Green, D. R. & Chipuck, J. E. Cell 126, 30–32 (2006).
Levine, B. & Kroemer, G. Cell 132, 27–42 (2008).
Feng, Z., Zhang, H., Levine, A. J. & Jin, S. Proc. Natl Acad. Sci. USA 102, 8204–8209 (2005).
Zeng, X., Yan, T., Schupp, J. E., Seo, Y. & Kinsella, T. J. Clin. Cancer Res. 13, 1315–1321 (2007).
Abida, W. M. & Gu, W. Cancer Res. 68, 352–357 (2008).
Crighton, D. et al. Cell 126, 121–134 (2006).
Amaravadi, R. K. et al. J. Clin. Invest. 117, 326–336 (2007).
Maclean, K. H., Dorsey, F. C., Cleveland, J. L. & Kastan, M. B. J. Clin. Invest. 118, 79–88 (2008).
Tasdemir, E. et al. Nature Cell Biol. 10, 676–687 (2008).
Maiuri, M. C., Zalckvar, E., Kimchi, A. & Kroemer, G. Nature Rev. Mol. Cell Biol. 8, 741–752 (2007).
Akdemir, F., Christich, A., Sogame, N., Chapo, J. & Abrams, J. M. Oncogene 26, 5184–5193 (2007).
Bourdon, J. C. et al. Genes Dev. 19, 2122–2137 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Levine, B., Abrams, J. p53: The Janus of autophagy?. Nat Cell Biol 10, 637–639 (2008). https://doi.org/10.1038/ncb0608-637
Issue Date:
DOI: https://doi.org/10.1038/ncb0608-637
This article is cited by
-
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway
Cell Death & Differentiation (2023)
-
The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
Cell Death Discovery (2022)
-
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
Cell Death & Disease (2022)
-
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma
Journal of Translational Medicine (2021)
-
Notch pathway: a bistable inducer of biological noise?
Cell Communication and Signaling (2019)