Abstract
The crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A, which forms part of the ribonucleoprotein complex involved in the excision of introns, has been solved. It contains a four-stranded β sheet and two α helices. The highly conserved segments designated RNP1 and RNP2 lie side by side on the middle two β strands. U1 RNA binding studies of mutant proteins suggest that the RNA binds to the four-stranded β sheet and to the flexible loops on one end.
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Nagai, K., Oubridge, C., Jessen, T. et al. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature 348, 515–520 (1990). https://doi.org/10.1038/348515a0
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DOI: https://doi.org/10.1038/348515a0