Abstract
IT has been shown that morphine will inhibit release of ACTH following exposure to stressors1,2. On the other hand, animals bearing tumours exhibit evidence of increased adrenal cortical secretion3,4. In view of the wide use of morphine and its derivatives in control of pain in persons with cancer, it was of interest to determine the effect of morphine administration on tumour-bearing animals. Because of the subsequent finding that carcass nitrogen in tumour-bearing rats was further decreased when morphine was administered, the effect of growth hormone, which has been found to reverse the anti-anabolic action of cortisone5, was investigated.
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References
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SOBEL, H., BONORRIS, G. Effect of Morphine on Rats bearing Walker Carcinosarcoma 256. Nature 196, 896–897 (1962). https://doi.org/10.1038/196896a0
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DOI: https://doi.org/10.1038/196896a0